Evidence map›Paper›PMID 41636494›Full record

ArticleNeurosurgery2026

Modified Integrated Health State Suggests Lower Cumulative Neck Pain-Related Disability After Cervical Disk Replacement Compared With Anterior Cervical Diskectomy and Fusion.

Tomoyuki Asada, Adin M Ehrlich, Sereen Halayqeh, Eric R Zhao, Adrian T H Lui, Andrea Pezzi, Austin C Kaidi, Kasra Araghi, Vishaal Nayagam, Roger Freeman and 13 more

Abstract readComparative Study
In one paragraph

Article in Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Tomoyuki AsadaDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York , New York , USA.ORCID 0000-0003-3470-5546
Adin M Ehrlich
Sereen Halayqeh
Eric R Zhao
Adrian T H Lui
Andrea Pezzi
Austin C Kaidi
Kasra Araghi
Vishaal Nayagam
Roger Freeman
Olivia C Tuma
Tarek Harhash
Harvinder S Sandhu
Todd J Albert
Han Jo Kim
James C Farmer
Russel C Huang
Matthew E Cunningham
Francis C Lovecchio
Kyle W Morse
James E Dowdell
Sheeraz A Qureshi

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002384
6 · The paper itself

Abstract

BACKGROUND AND

objectivesAnterior cervical diskectomy and fusion (ACDF) and cervical disk replacement (CDR) are common options for cervical degenerative radiculopathy. While previous studies indicate comparable early outcomes at discrete time point, few have quantified cumulative postoperative disability over a year to compare these procedures. To develop novel cumulative postoperative disability and compare the metric between ACDF and CDR.

methodsThis is a retrospective study analyzing 327 patients undergoing primary 1- or 2-level ACDF or CDR for degenerative cervical radiculopathy between February 2016 and September 2024 in a single institution. Cumulative postoperative disability was quantified as the modified integrated health status (mIHS), which was area under the curve per week of the 1-year normalized Neck Disability Index modeled using mixed-effects regression. Baseline differences were adjusted using overlap weighting based on propensity scores.

resultsThe mIHS demonstrated acceptable construct and modest concurrent validity. The mixed-effects model indicated significantly different recovery trajectories between groups ( P < .001). The mIHS was significantly higher for ACDF than for CDR (3.71 vs 2.68; mean difference, 1.03 [95% CI, 0.80-1.25], P < .001). Level-specific analyses showed that 1-level CDR showed a 21.5% lower mIHS than 1-level ACDF ( P < .001), whereas 2-level CDR had a 32.1% lower mIHS than 2-level ACDF ( P < .001). The 2-level ACDF showed greater mIHS than 1-level ACDF (3.47 vs 3.89; P = .012), whereas 1-level CDR and 2-level CDR were comparable (2.76 vs 2.64; P = .59).

conclusionCDR was associated with less cumulative postoperative disability during the first year compared with ACDF. Two-level CDR resulted in disability comparable with 1-level CDR, whereas 2-level ACDF showed greater disability than 1-level ACDF.

Indexed as

Cervical VertebraeDiskectomyNeck PainSpinal FusionTotal Disc ReplacementAdultDisability EvaluationFemaleHealth StatusHumansMaleMiddle AgedRadiculopathyRetrospective StudiesTreatment OutcomeACDFCDRIntegrated health stateMixed-effects modelNDIOutcomePostoperative disability

Identifiers

PMID41636494
PMCPMC13170703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.