ArticleHuman vaccines & immunotherapeutics2026
Impact of intralesional tuberculin PPD injection on anogenital warts: Interferon-α, interleukin-2, and treatment outcomes.
Pati Aji Achdiat, Oki Suwarsa, Yudi Mulyana Hidayat, Reiva Farah Dwiyana, Mohamad Nasir Shafiee, Reti Hindritiani, Endang Sutedja, Satiti Retno Pudjiati, Dany Hilmanto, Ida Parwati and 4 more
Abstract read
In one paragraphArticle in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Pati Aji AchdiatDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0002-3010-5052 Oki SuwarsaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0003-4017-9319 Yudi Mulyana HidayatDoctoral Program in Medical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0002-8010-5907 Reiva Farah DwiyanaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0001-9350-0239 Mohamad Nasir ShafieeDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.ORCID 0000-0001-5631-5309 Reti HindritianiDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0002-9753-0387 Endang SutedjaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0002-6960-4895 Satiti Retno PudjiatiDepartment of Dermatology and Venereology, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.ORCID 0000-0001-9235-759X Dany HilmantoDoctoral Program in Medical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0003-3684-4144 Ida ParwatiDoctoral Program in Medical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Meita DhamayantiDoctoral Program in Medical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0001-9661-0708 Reyshiani JohanDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0009-0004-0843-998X Ivan Daniel BanjarnahorDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0001-7644-0510 Retno Hesty MaharaniDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0002-4483-3552 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The clinical manifestation of anogenital warts (AGW) resulting from Human Papillomavirus (HPV) infection is influenced by host immune responses. Interferon (IFN)-α contributes to antiviral activity, while Interleukin (IL)-2 plays an important role in cellular immunity. Tuberculin purified protein derivative (TPPD) has been investigated as an immunotherapeutic agent. This exploratory quasi-experimental study analyzed 12 AGW patients treated with intralesional TPPD (5 tuberculin units weekly for six injections). Tissue samples were collected at baseline and week 2, and serum samples at baseline and week 6. IFN-α and IL-2 expression in tissue was assessed using immunohistochemistry (IHC), and serum levels were measured using ELISA. TPPD therapy was associated with increased IFN-α and IL-2 expression in tissue (
Indexed as
Condylomata AcuminataInterferon-alphaInterleukin-2TuberculinAdolescentAdultEnzyme-Linked Immunosorbent AssayFemaleHumansImmunohistochemistryInjections, IntralesionalMaleTreatment OutcomeYoung AdultInterferon-alphaInterleukin-2TuberculinAnogenital wartsimmunohistochemistryimmunotherapyinterferon-αinterleukin-2serumtreatment responsetuberculin purified protein derivative
Identifiers
PMID41636473
PMCPMC12885424
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