Evidence map›Paper›PMID 41636199›Full record

ArticleEuropean journal of immunology2026

Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements.

Mariam A Salem, Aditi Varkey, Matthew D Estrada, Kruthika Sharma, Caprice D Eisele, Nitin Chakravarti, Dean A Lee, Aharon G Freud, Bethany L Mundy-Bosse, Patrick L Collins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mariam A SalemDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Aditi VarkeyDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Matthew D EstradaDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Kruthika SharmaDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Caprice D EiseleDepartment of Pathology, The Ohio State University, Columbus, Ohio, USA.
Nitin ChakravartiDivision of Hematologic Malignancies, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Dean A LeeDepartment of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Aharon G FreudDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Bethany L Mundy-BosseDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Patrick L CollinsDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-4550-4272

Funding

Dysregulation of Innate Lymphoid Immunity in Acute Myeloid LeukemiaR01CA255860 · NCI · OHIO STATE UNIVERSITY · PI MUNDY-BOSSE, BETHANY, OAKES, CHRISTOPHER C. · 2021 to 2025
$2.5M
Gene regulatory architecture of CD56 bright natural killer cellsR21AI156411 · NIAID · OHIO STATE UNIVERSITY · PI COLLINS, PATRICK LEONARD · 2021 to 2022
$433k
NCI NIH HHS R01 CA255860NIAID NIH HHS R21 AI156411NIH HHS R01CA255860NIH HHS r21AI156411
6 · The paper itself

Abstract

Owing to their immunoprotective properties, natural killer (NK) cells are critical for the innate immune response to pathogens, as well as a new wave of cancer immunotherapy that harnesses natural cytotoxicity. We sought to study the genetic and epigenetic drivers behind human-specific NK cell receptors, so that we can better understand the underlying cellular function. Here, we present a transcriptomic, proteomic (CITE-seq), and chromatin (single nuclei ATAC-seq) profiling of human peripheral NK cell subsets, which was then compared with genomic databases. Through integrative multi-omics, we demonstrate that CD56

Indexed as

CD56 AntigenKiller Cells, NaturalRegulatory Sequences, Nucleic AcidEpigenesis, GeneticGene Expression ProfilingGene Expression RegulationHumansReceptors, Natural Killer CellCD56 AntigenNCAM1 protein, humanReceptors, Natural Killer CellepigeneticshumanimmunologyNK cellsingle nuclei ATAC‐seq

Identifiers

PMID41636199
PMCPMC12869470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.