ArticleActa physiologica (Oxford, England)2026
WDR72 Is Required for Urinary Acidification and Normal H
Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Renal cysts in WDR72-associated distal renal tubular acidosis: expanding the phenotypic spectrum.CEN case reports · 2026Article
- WDR72 Is Required for Urinary Acidification and Normal HActa physiologica (Oxford, England) · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
aimBiallelic inactivating WDR72 variants are linked to distal renal tubular acidosis (dRTA), nephrocalcinosis, and amelogenesis imperfecta. The kidney shows high WDR72 expression; its precise localization and function remain unclear. WDR72 is a member of the WD40 repeat domain protein family-a large group of scaffold proteins involved in various pathways, including vesicular trafficking-which has been suggested as a potential role for WDR72. This study investigates WDR72 expression and its role in renal acid-base homeostasis.
methodsWe analyzed WDR72/Wdr72 expression in single-cell transcriptome data from human and murine kidneys. We characterized Wdr72
resultsTranscriptome data showed that WDR72/Wdr72 is highly expressed in intercalated cells and other nephron segments. Immunohistochemistry localized WDR72 mostly at the apical membrane of type A-intercalated cells (A-IC). Wdr72
conclusionThese findings identify WDR72 as a critical regulator of type A-intercalated cell dependent urinary acidification, modulating H
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