Evidence map›Paper›PMID 41636028›Full record

ArticleHypertension (Dallas, Tex. : 1979)2026

Endothelial LRRC8C Associates With LRRC8A and LRRC8B to Regulate Vascular Reactivity and Blood Pressure.

Qiujun Yu, Yonghui Zhao, Joshua Maurer, Prakash Arullampalam, Nathaniel John, John D Tranter, Tarek Mohamed Abd El-Aziz, Mehran Rahimi, Michelle Lin, Carmen M Halabi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Qiujun YuDepartment of Internal Medicine, Cardiovascular Division (Q.Y., Y.Z., J.M., P.A., N.J., J.D.T., T.M.A.E.-A., M.R., R.S.), Washington University School of Medicine, Saint Louis, MO.ORCID 0000-0003-0690-138X
Yonghui ZhaoDepartment of Internal Medicine, Cardiovascular Division (Q.Y., Y.Z., J.M., P.A., N.J., J.D.T., T.M.A.E.-A., M.R., R.S.), Washington University School of Medicine, Saint Louis, MO.ORCID 0000-0002-6192-4130
Joshua MaurerDepartment of Internal Medicine, Cardiovascular Division (Q.Y., Y.Z., J.M., P.A., N.J., J.D.T., T.M.A.E.-A., M.R., R.S.), Washington University School of Medicine, Saint Louis, MO.
Prakash ArullampalamDepartment of Internal Medicine, Cardiovascular Division (Q.Y., Y.Z., J.M., P.A., N.J., J.D.T., T.M.A.E.-A., M.R., R.S.), Washington University School of Medicine, Saint Louis, MO.ORCID 0000-0001-5725-2290
Nathaniel JohnDepartment of Internal Medicine, Cardiovascular Division (Q.Y., Y.Z., J.M., P.A., N.J., J.D.T., T.M.A.E.-A., M.R., R.S.), Washington University School of Medicine, Saint Louis, MO.
John D TranterDepartment of Internal Medicine, Cardiovascular Division (Q.Y., Y.Z., J.M., P.A., N.J., J.D.T., T.M.A.E.-A., M.R., R.S.), Washington University School of Medicine, Saint Louis, MO.ORCID 0009-0006-6884-7154
Tarek Mohamed Abd El-AzizDepartment of Internal Medicine, Cardiovascular Division (Q.Y., Y.Z., J.M., P.A., N.J., J.D.T., T.M.A.E.-A., M.R., R.S.), Washington University School of Medicine, Saint Louis, MO.
Mehran RahimiDepartment of Internal Medicine, Cardiovascular Division (Q.Y., Y.Z., J.M., P.A., N.J., J.D.T., T.M.A.E.-A., M.R., R.S.), Washington University School of Medicine, Saint Louis, MO.
Michelle LinDepartment of Pediatrics, Division of Nephrology (M.L., C.M.H.), Washington University School of Medicine, Saint Louis, MO.ORCID 0000-0001-5367-1930
Carmen M HalabiDepartment of Pediatrics, Division of Nephrology (M.L., C.M.H.), Washington University School of Medicine, Saint Louis, MO.ORCID 0000-0003-4889-8131
Rajan SahDepartment of Internal Medicine, Cardiovascular Division (Q.Y., Y.Z., J.M., P.A., N.J., J.D.T., T.M.A.E.-A., M.R., R.S.), Washington University School of Medicine, Saint Louis, MO.

Funding

Tuning fat cell size and obesity through SWELL1R01DK106009 · NIDDK · WASHINGTON UNIVERSITY · PI SAH, RAJAN · 2016 to 2024
$3.8M
LRRC8 complex regulation of endothelial functionR01HL168600 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Rajan Sah · 2023 to 2026
$2.3M
Optimizing small molecule SWELL1-LRRC8 modulators to treat Type 2 diabetesR01DK126068 · NIDDK · WASHINGTON UNIVERSITY · PI SAH, RAJAN · 2021 to 2025
$2.0M
SWELL1-LRRC8 mediated regulation of skeletal muscle function and metabolismR01DK127080 · NIDDK · WASHINGTON UNIVERSITY · PI SAH, RAJAN · 2021 to 2024
$1.7M
BLRD VA I01 BX005072NHLBI NIH HHS R01 HL168600NIDDK NIH HHS R01 DK106009NIDDK NIH HHS R01 DK126068NIDDK NIH HHS R01 DK127080
6 · The paper itself

Abstract

backgroundEndothelial mechanosensing is essential for controlling vascular tone. LRRC8A (leucine-rich repeat-containing protein 8A) was previously identified as a core subunit of the mechanoresponsive LRRC8 complex, functionally encoding the endothelial volume regulatory anion channel and regulating vascular function. This study aims to identify the molecular identity of the endothelial LRRC8 complex and its function in vascular reactivity and blood pressure control.

methodsWe generated germline epitope-tagged

resultsAlthough all LRRC8A-E subunits are expressed in endothelium, co-immunoprecipitation revealed enrichment of LRRC8A/B/C, suggesting the existence of an endothelial LRRC8A/B/C heteromer.

conclusionsLRRC8A/B/C form the endothelial LRRC8 heteromeric complex. LRRC8C is nonredundant in supporting endothelial AKT-endothelial NO synthase signaling, vascular relaxation, and resistance to hypertension.

Indexed as

Blood PressureEndothelium, VascularHypertensionMembrane ProteinsAnimalsDisease Models, AnimalMaleMesenteric ArteriesMiceMice, KnockoutNitric Oxide Synthase Type IIISignal TransductionVasodilationLRRC8A protein, mouseMembrane ProteinsNitric Oxide Synthase Type IIIendotheliumhypertensionion channelsnitric oxidevasodilation

Identifiers

PMID41636028
PMCPMC13011911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.