ArticleGenome biology and evolution2026
Trio-sequencing Reveals High Germline Mutation Rates in the Colorado Potato Beetle (Leptinotarsa decemlineata).
Article in Genome biology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Differential Demographic Trajectories and Polygenic Adaptation to Monsoon Seasonality in Sky Island Hercules Beetle Populations of the American Southwest.Molecular ecology · 2026Article
- Ambrosia beetle invasions are structured by inbreeding, intraspecific hybridization, and bridgeheads.Molecular biology and evolution · 2026Article
- Bacterial DNA invasion triggers transposable element proliferation and genome expansion.bioRxiv : the preprint server for biology · 2026Article
- Chromosome-Level Reference Genome of an Endemic, Endangered Long-Armed Scarab (Ecology and evolution · 2026Article
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Authors and funding
4 authors.
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Abstract
Germline mutation rates are fundamental to evolution, yet they remain unquantified for beetles (Coleoptera), the most speciose order including major pests. We sequenced genomes from 16 trios of the Colorado potato beetle (Leptinotarsa decemlineata, CPB)-a pest that has evolved resistance to many insecticides. We estimated a germline mutation rate of 5.8 × 10-9 (95% CI: 4.7 × 10-9, 7.2 × 10-9) per site per generation in CPB, a rate 2-fold higher than the median for other insects. Across 13 insect species, mutation rate was positively associated with genome-wide GC content (PGLS). The increased mutation rate in CPB is also consistent with drift-barrier expectations. Based on this mutation rate and the beetle's fecundity, we estimate that the brood from just one CPB female can introduce nearly 141 new mutations into the coding regions each generation. These findings inform CPB's rapid pesticide resistance evolution and fill a key gap in arthropod genomics and evolution.
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