Evidence map›Paper›PMID 41635782›Full record

ArticleNAR molecular medicine2026

The fluoropyrimidine polymer CF10 synergizes with 5-ethynyl-2'-deoxyuridine by promoting telomere attrition and mitotic catastrophe.

Upasana Das, Akanksha Behl, William H Gmeiner

Abstract read
In one paragraph

Article in NAR molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Upasana DasDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States.
Akanksha BehlDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States.
William H GmeinerDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States.ORCID https://orcid.org/0000-0003-1883-3791

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Nanodelivery of FP polymers to improve treatment of metastatic colorectal cancerR01CA284083 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI William H. Gmeiner · 2023 to 2026
$2.3M
Modified Thrombin Binding Aptamer Treatment of CRC MetastasisR41CA302074 · NCI · DEEP CREEK PHARMA, LLC · PI GMEINER, WILLIAM H. · 2025 to 2025
$400k
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA284083NCI NIH HHS R41 CA302074
6 · The paper itself

Abstract

Fluoropyrimidine (FP) drugs, including 5-fluorouracil (5FU), are widely used to treat colorectal cancer (CRC) and target

Identifiers

PMID41635782
PMCPMC12862372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.