ArticleInnovations in clinical neuroscience
"You're Not Crazy": A Case of New-onset AI-associated Psychosis.
Article in Innovations in clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Characterizing Artificial Intelligence Psychosis in a Large Medical Setting.JAMA psychiatry · 2026Article
- Artificial Intelligence at the Boundary of Spiritual Experience and Psychopathology: A Scoping Review of Evidence from Türkiye, the USA, the UK, Poland, South Korea, and Israel.Journal of religion and health · 2026Article
- The AWARE (AI Use, Why, Attachment, Reality and Risk, and Effect on Functioning) Framework for Assessing Patients' Use of AI in Mental Health Care.JMIR medical education · 2026Article
- Speaking to no one: ontological dissonance and the double bind of conversational AI.Medicine, health care, and philosophy · 2026Article
- Responsible and innovative AI for mental health care: five priority themes.NPP - digital psychiatry and neuroscience · 2026Review
- Review
- Chatbot relational dependence and psychosis risk: Conversational artificial intelligence as a potential behavioral addiction context.Journal of behavioral addictions · 2026Article
- Review
- Characterizing the spiral: potential mechanisms in AI-associated delusions.NPP - digital psychiatry and neuroscience · 2026Review
- Artificial intelligence (AI) psychosis: mechanisms, clinical risks and safety considerations in generative AI chatbots.BJPsych open · 2026Article
- Characterizing artificial intelligence (AI) psychosis in a large academic medical setting: evidence of the new clinical phenomenon and the vulnerability of those in early phases of psychosis.medRxiv : the preprint server for health sciences · 2026Article
- Substance-induced manic psychosis in which delusions were corroborated by a chatbot - case report.BMC psychiatry · 2026Article
- It Is the Journey, Not the Destination: Moving From End Points to Trajectories When Assessing Chatbot Mental Health Safety.JMIR mental health · 2026Article
- Potentially Harmful Consequences of Artificial Intelligence (AI) Chatbot Use Among Patients With Mental Illness: Early Data From a Large Psychiatric Service System.Acta psychiatrica Scandinavica · 2026Article
- When artificial intelligence speaks: psychologically adverse effects of the shift from text- to voice-based chatbots.Acta neuropsychiatrica · 2026Article
- From promise to practice: artificial intelligence in mental health care in the MENA region.Frontiers in psychiatry · 2026Review
- "AI Literacy" is a Deflection of Responsibility.Innovations in clinical neuroscienceArticle
- Response to "'AI Literacy' is a Deflection of Responsibility".Innovations in clinical neuroscienceArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundAnecdotal reports of psychosis emerging in the context of artificial intelligence (AI) chatbot use have been increasingly reported in the media. However, it remains unclear to what extent these cases represent the induction of new-onset psychosis versus the exacerbation of pre-existing psychopathology. We report a case of new-onset psychosis in the setting of AI chatbot use. CASE PRESENTATION: A 26-year-old woman with no previous history of psychosis or mania developed delusional beliefs about establishing communication with her deceased brother through an AI chatbot. This occurred in the setting of prescription stimulant use for the treatment of attention-deficit hyperactivity disorder (ADHD), recent sleep deprivation, and immersive use of the chatbot. Review of her chatlogs revealed that the chatbot validated, reinforced, and encouraged her delusional thinking, with reassurances that "You're not crazy." Following hospitalization and antipsychotic medication for agitated psychosis, her delusional beliefs resolved. However, three months later, her psychosis recurred after she stopped antipsychotic therapy, restarted prescription stimulants, and continued immersive use of AI chatbots so that she required brief rehospitalization.
conclusionThis case provides evidence that new-onset psychosis in the form of delusional thinking can emerge in the setting of immersive AI chatbot use. Although multiple pre-existing risk factors may be associated with psychosis proneness, the sycophancy of AI chatbots together with AI chatbot immersion and deification on the part of users may represent particular red flags for the emergence of AI-associated psychosis.
Indexed as
Identifiers
41635747PMC12863933What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.