Evidence map›Paper›PMID 41635733›Full record

ArticleFood science & nutrition2026

Virtual Screening of Phytochemicals From Medicinal Plants as Promising PDE5 Inhibitors Against Erectile Dysfunction.

Farouk Boudou, Alaeddine Berkane, Amal Belakredar, Ahcene Keziz, Huda Alsaeedi, Brian A Murray, Mikhael Bechelany, Ahmed Barhoum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Farouk BoudouDepartment of Applied Molecular Genetics, Faculty of Natural and Life Sciences University of Science and Technology of Oran Oran Algeria.ORCID https://orcid.org/0000-0002-6008-3325
Alaeddine BerkaneLaboratory of Chemistry, Synthesis, Properties, and Applications (LCSPA), Department of Chemistry, Faculty of Sciences Dr. Moulay Tahar University of Saida Saida Algeria.
Amal BelakredarDepartment of Biotechnology, Faculty of Natural Sciences and Life University of Mostaganem Abdelhamid Ibn Badis Mostaganem Algeria.
Ahcene KezizDepartment of Physics, and Chemistry of Materials Laboratory University of M'sila M'sila Algeria.
Huda AlsaeediDepartment of Chemistry College of Science, King Saud University Riyadh Saudi Arabia.
Brian A MurrayChemical and BioPharmaceutical Sciences Technological University Dublin Dublin Ireland.
Mikhael BechelanyInstitut Européen Des Membranes (IEM), UMR 5635, Univ Montpellier, ENSCM, CNRS Montpellier France.
Ahmed BarhoumNanoStruc Research Group, Chemistry Department, Faculty of Science Helwan University Cairo Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluates bioactive phytochemicals from Algerian medicinal plants as potential phosphodiesterase-5 (PDE5) inhibitors for the treatment of erectile dysfunction (ED) using an integrated in silico approach. A total of 76 compounds from 48 plant species were screened for drug-likeness using SwissADME. Overall, 72% of the compounds complied with Lipinski's Rule of Five, indicating favorable oral bioavailability, while toxicity prediction identified 29 non-toxic candidates. Molecular docking was validated by redocking the co-crystallized PDE5 ligand (RMSD = 0.264 Å). Ellagic acid (-9.4 kcal·mol

Indexed as

algerian medicinal plantsdrug‐likenesserectile dysfunctionmolecular dockingmolecular dynamicsPDE5 inhibitionQSARtoxicity assessment

Identifiers

PMID41635733
PMCPMC12862184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.