Evidence map›Paper›PMID 41635728›Full record

ArticleFrontiers in cardiovascular medicine2025

Coronary complexity and inflammatory burden in HIV-infected patients with acute coronary syndrome: a two-year prospective cohort study in China.

Qiang Wu, Liqin Sun, Chunxiao Lu, Lina Zhang, Siwei Jiang, Wenhui Xu, Niuniu Li, Yifan Zhang, Meixia Chen, Xianjia Ning and 4 more

Abstract read
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In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qiang Wu *Department of Geriatrics, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Liqin Sun *Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Chunxiao Lu *Department of Pediatrics, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Lina ZhangDepartment of Liver Diseases, Shenzhen Third People's Hospital, Shenzhen, China.
Siwei JiangDepartment of Geriatrics, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Wenhui XuDepartment of Geriatrics, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Niuniu LiDepartment of Geriatrics, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Yifan ZhangDepartment of Geriatrics, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Meixia ChenDepartment of Geriatrics, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Xianjia NingCenter of Clinical Epidemiology, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Jinghua WangCenter of Clinical Epidemiology, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Fei WangDepartment of Geriatrics, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Juan MengDepartment of Geriatrics, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.
Hong GaoDepartment of Geriatrics, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, the Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives: People living with HIV (PLWH) are increasingly at risk for cardiovascular disease (CVD) due to chronic inflammation, metabolic dysregulation, and long-term antiretroviral therapy (ART). However, limited data exist regarding coronary anatomy and long-term outcomes in PLWH with acute coronary syndrome (ACS), particularly in Chinese populations. This study aimed to compare coronary angiographic characteristics, metabolic-inflammatory profiles, and 2-year prognosis between PLWH and HIV-uninfected patients with ACS. Methods: We conducted a single-center observational cohort study including 129 patients with a first episode of ACS between 2019 and 2023. 43 PLWH were analyzed with 86 HIV-uninfected controls. Coronary artery lesions were assessed by angiography and SYNTAX score. Laboratory parameters including CRP and lipid levels, among others, were collected. The primary outcome was the incidence of major adverse cardiovascular and cerebrovascular events during the 2-year follow-up period. Results: PLWH had significantly higher SYNTAX scores compared to HIV-free patients (21.56 vs. 16.77, Conclusion: PLWH with ACS have more complex coronary heart disease and a higher risk of recurrence, partly due to vascular calcific changes. These findings suggest the need for enhanced metabolic monitoring and individualized secondary prevention strategies in this high-risk population.

Indexed as

acute coronary syndromecoronary angiographyHIV infectioninflammationtriglycerides

Identifiers

PMID41635728
PMCPMC12862469

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