Observational studyFrontiers in cellular and infection microbiology2025
Characteristics of pathogenic microorganisms in COPD-related infections: prognostic correlations and implications.
Observational study in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic obstructive pulmonary disease (COPD) significantly impacts global health, primarily due to frequent acute exacerbations caused by respiratory infections. Precise microbial characterization may inform prognostic insights and optimize clinical management. Methods: We conducted a prospective observational study from December 2023 to February 2025 involving 1146 patients (259 COPD; 887 non-COPD) with suspected respiratory infections. Bronchoalveolar lavage fluid samples underwent next-generation sequencing (NGS) and conventional microbiological testing. Multivariate logistic regression identified COPD predictors, and machine learning modeled prognostic outcomes based on microbial profiles. Results: Distinct pathogen distributions emerged between COPD and non-COPD groups, with COPD patients exhibiting higher prevalence of gram-negative bacteria, particularly Conclusions: Comprehensive microbial profiling using NGS effectively distinguishes pathogen differences between COPD and non-COPD patients, revealing key associations with clinical prognosis. These insights can inform tailored clinical interventions aimed at mitigating COPD exacerbations and improving patient outcomes.
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