Evidence map›Paper›PMID 41635716›Full record

ArticleFrontiers in cellular and infection microbiology2025

Analysis of factors influencing latent tuberculosis infection screening using QuantiFERON-TB Gold In-Tube in people living with HIV/AIDS.

Yiming Xu, Jincheng Li, Song Gao, Yuying Huang, Qi Zhang, Huan Ding, Shipeng Zhang, Shiya Shen, Zhuping Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yiming Xu *School of Public Health, Nanjing Medical University, Nanjing, China.
Jincheng Li *Department of Chronic Infectious Disease Control and Prevention, Yangzhou Center for Disease Control and Prevention, Yangzhou, China.
Song Gao *Department of Chronic Infectious Disease Control and Prevention, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Yuying Huang *School of Public Health, Nanjing Medical University, Nanjing, China.
Qi ZhangDepartment of Chronic Infectious Disease Control and Prevention, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Huan DingDepartment of Chronic Infectious Disease Control and Prevention, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Shipeng ZhangDepartment of Chronic Infectious Disease Control and Prevention, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Shiya ShenDepartment of Chronic Infectious Disease Control and Prevention, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Zhuping XuSchool of Public Health, Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the influencing factors associated with the risk of latent tuberculosis infection (LTBI) among people living with HIV/AIDS (PLWHA). Methods: A cross-sectional study was conducted from July 2023 to July 2024, recruiting PLWHA from Wuxi City and Yangzhou City, Jiangsu Province, China. Data were collected through on-site questionnaire surveys and review of patient disease management records. QuantiFERON-TB Gold In-Tube (QFT) was used to detect LTBI. Multivariate logistic regression analysis was performed to identify factors associated with LTBI among PLWHA. Restricted cubic splines (RCS) models were employed to analyze the dose-response relationships between CD4 Results: A total of 1184 PLWHA were enrolled, with 8.4% having concomitant LTBI. Multivariate logistic regression revealed that age group 45-<60 years (OR = 2.158, 95% Conclusion: This study identified that middle-aged PLWHA (45-<60 years) might represent a subgroup with relatively higher LTBI prevalence, indicating that screening in this age group may hold greater potential value. Additionally, the CD4/CD8 ratio, in conjunction with QFT findings, could serve as a supplementary reference for LTBI risk assessment. These observations support a more tailored approach to LTBI screening in PLWHA, though their implementation should be validated in prospective studies.

Indexed as

HIV InfectionsInterferon-gamma Release TestsLatent TuberculosisMass ScreeningAdultCD4-CD8 RatioCD4 Lymphocyte CountChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsYoung AdultHIVlatent tuberculosis infectionQFTrestricted cubic splines (RCS)tuberculosis

Identifiers

PMID41635716
PMCPMC12862061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.