ArticleActa clinica Croatica2025
THROMBOTIC RISK EVALUATION OF TWO METHYLENETETRAHYDROFOLATE REDUCTASE MUTATIONS C677t AND A1298c IN VENOUS THROMBOEMBOLISM.
Article in Acta clinica Croatica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The MTHFR mutations C677T and A1298C combined with folate and vitamin B12 deficiency lead to hypercoagulability. We evaluated thrombotic risk due to MTHFR mutations, individually and in combination, in patients with venous thromboembolism (VTE). The case-control study included groups of 262 VTE patients and 101 healthy controls. Allelic distribution of MTHFR C677T/A1298C mutations was determined by real-time polymerase chain reaction and results were statistically analyzed using χ
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