ArticleFrontiers in neurology2025
Admission NIHSS score and diabetes as independent predictors of in-hospital early neurological improvement following mechanical thrombectomy: a retrospective cohort study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Accurate early prognostication in acute ischemic stroke (AIS) is essential for optimizing post-thrombectomy management strategies. However, the predictive utility of baseline clinical characteristics remains underexplored in real-world emergency settings. Objective: To identify independent clinical predictors of in-hospital neurological improvement following mechanical thrombectomy in AIS patients, with particular focus on admission NIHSS score and comorbid diabetes mellitus. Methods: In this retrospective single-center cohort study, 250 AIS patients who underwent emergency mechanical thrombectomy between January 2020 and December 2022 were analyzed. Patients were dichotomized according to an in-hospital early neurological improvement endpoint defined Results: Among the 250 patients, 196 (78.4%) showed neurological improvement during hospitalization. Multivariate logistic regression revealed that a lower admission NIHSS score (OR = 0.867, 95% CI: 0.810-0.927; Conclusion: Lower NIHSS scores at presentation and non-diabetic status are independent predictors of early neurological improvement following thrombectomy. The internally validated model provides a clinically accessible tool for early risk stratification in AIS patients and may inform post-procedural monitoring and care planning in settings lacking long-term functional follow-up.
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