Evidence map›Paper›PMID 41635530›Full record

ArticleSurgical case reports2026

Spontaneous Regression of Intrahepatic Adenocarcinoma after Needle Biopsy: A Case Report and Literature Review.

Koetsu Inoue, Tatsunori Bandai, Naota Okabe, Masahiro Hiruta, Hisashi Oshiro, Yuki Mizusawa, Hidetoshi Aizawa, Yuhei Endo, Fumiaki Watanabe, Hiroshi Noda and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Koetsu InoueDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan.
Tatsunori BandaiDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan.
Naota OkabeDepartment of Pathology, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan.
Masahiro HirutaDepartment of Pathology, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan.
Hisashi OshiroDepartment of Pathology, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan.
Yuki MizusawaDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan.
Hidetoshi AizawaDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan.
Yuhei EndoDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan.
Fumiaki WatanabeDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan.
Hiroshi NodaDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan.
Toshiki RikiyamaDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSpontaneous tumor regression (STR) is a rare phenomenon in which cancer cells partially or completely disappear without treatment. We report a case of intrahepatic cholangiocarcinoma demonstrating STR following endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA). CASE PRESENTATION: A 77-year-old male presented with acute cholecystitis 1 day after percutaneous coronary intervention for acute myocardial infarction. Conservative treatment and endoscopic retrograde gallbladder drainage were performed due to antiplatelet therapy. Cytology of bile juice unexpectedly revealed adenocarcinoma. Further imaging, including CT and mapping biopsy, failed to detect a tumor. Laparoscopic cholecystectomy with gallbladder bed resection showed no histological evidence of malignancy. Four months later, surveillance CT revealed a 15 × 15 mm lesion in segment 3 of the liver. EUS-FNA confirmed adenocarcinoma. Laparoscopic left lateral resection was performed; however, no viable cancer cells were identified, and the lesion was replaced by epithelioid granulomas. Immunohistochemistry demonstrated dense infiltration of CD8-positive cytotoxic T cells, suggesting an immune-mediated regression of the tumor.

conclusionsThis case highlights the possibility of tumor regression in intrahepatic adenocarcinoma following EUS-FNA, potentially triggered by an immune response.

Indexed as

CD8-positive T cellintrahepatic cholangiocarcinomaspontaneous tumor regression

Identifiers

PMID41635530
PMCPMC12862458

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