Evidence map›Paper›PMID 41635507›Full record

ArticleInternational journal of analytical chemistry2026

Development and Validation of a Robust RP-HPLC Method for Quantifying Dasatinib in Self-Microemulsifying Drug Delivery Systems.

Nitin V Kokare, Rohit R Shah, Rana Salman Saad Al-Rashidi, Kuntal Das, Syed Mohammed Basheeruddin Asdaq, Walaa F Alsanie, Abdulhakeem S Alamri, Majid Alhomrani, Amal F Alshammary, Syed Arif Hussain and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nitin V KokareDepartment of Quality Assurance, Appasaheb Birnale College of Pharmacy, Sangli, 416416, Maharashtra, India.
Rohit R ShahDepartment of Pharmaceutics, Appasaheb Birnale College of Pharmacy, Sangli, 416416, Maharashtra, India.
Rana Salman Saad Al-RashidiDepartment of Pharmacy, King Khalid University Hospital, Riyadh, 11472, Saudi Arabia, ksu.edu.sa.
Kuntal DasSree Siddaganga College of Pharmacy, 3rd Block Mahalakshmi Nagar Near Railway Gate 80 feet Road Batawadi, Tumkur, 572013, Karnataka, India.
Syed Mohammed Basheeruddin AsdaqDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, 13713, Saudi Arabia, um.edu.sa.ORCID https://orcid.org/0000-0003-1533-9667
Walaa F AlsanieDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif, 21944, Saudi Arabia, tu.edu.sa.
Abdulhakeem S AlamriDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif, 21944, Saudi Arabia, tu.edu.sa.
Majid AlhomraniDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif, 21944, Saudi Arabia, tu.edu.sa.
Amal F AlshammaryDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 11472, Saudi Arabia, ksu.edu.sa.
Syed Arif HussainDepartment of Respiratory Care, College of Applied Sciences, AlMaarefa University, Dariyah, Riyadh, 13713, Saudi Arabia, um.edu.sa.
Syed Imam RabbaniDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, 51452, Saudi Arabia, qu.edu.sa.
Hanumantharayappa BylappaDepartment of Pharmacology, Mallige College of Pharmacy, #71, Silvepura, Chikkabanavara Post, Bangalore, 560090, India, mallige.ac.in.
Sultan AlshehriDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia, ksu.edu.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dasatinib, a therapy for chronic myeloid leukemia, suffers from poor bioavailability. Self-microemulsifying drug delivery systems (SMEDDSs) are used to improve its dissolution. This study aimed to develop and validate a novel reverse-phase high-performance liquid chromatography (RP-HPLC) method for quantifying dasatinib in SMEDDS formulations. The RP-HPLC method utilized a mobile phase of methanol and 0.1% trifluoroacetic acid (55:45, v/v) and identified a peak wavelength for dasatinib at 324 nm. SMEDDS formulations comprised Capryol 90, Transcutol HP, and Tween 40. The method was validated according to ICH guidelines, demonstrating excellent linearity (

Indexed as

dasatinibdrug designformulationreverse-phase HPLCstabilityvalidation

Identifiers

PMID41635507
PMCPMC12862106

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.