Evidence map›Paper›PMID 41635496›Full record

ArticleRSC advances2026

Organoselenium-based Schiff bases and amidic acid derivatives as promising anticancer agents targeting breast cancer by downregulating BCL-2: design, synthesis, and biological evaluation.

Saad Shaaban, Samia S Hawas, Asma M Elsharif, Marwa Sharaky, Hussein Ba-Ghazal, Mohamed Alaasar, Fatema S Alatawi, Khadra B Alomari, Mohamed E Eissa, Arwa Omar Al Khatib and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Saad ShaabanDepartment of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia sibrahim@kfu.edu.sa.ORCID https://orcid.org/0000-0002-7835-6926
Samia S HawasDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt.
Asma M ElsharifDepartment of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University Dammam 31441 Saudi Arabia.
Marwa SharakyCancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University Cairo Egypt.
Hussein Ba-GhazalDepartment of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia sibrahim@kfu.edu.sa.
Mohamed AlaasarDepartment of Chemistry, Faculty of Science, Cairo University Giza Egypt.ORCID https://orcid.org/0000-0003-4155-8644
Fatema S AlatawiDepartment of Biochemistry, Faculty of Science, University of Tabuk Tabuk Saudi Arabia.
Khadra B AlomariJazan University, Department of Physical Sciences, Chemistry Division P.O. Box 114 Jazan 45142 Kingdom of Saudi Arabia.
Mohamed E EissaDepartment of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh 11623 Saudi Arabia.
Arwa Omar Al KhatibFaculty of Pharmacy, Al-Ahliyya Amman University Amman Jordan.
Radwan AlnajjarDepartment of Chemistry, Faculty of Science, University of Benghazi Benghazi Libya.ORCID https://orcid.org/0000-0003-1869-9596
Ahmed A Al-KarmalawyDepartment of Pharmaceutical Chemistry, College of Pharmacy, The University of Mashreq Baghdad 10023 Iraq akarmalawy@horus.edu.eg.ORCID https://orcid.org/0000-0002-8173-6073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study reports the biological evaluation of novel Schiff base-tethered organoselenium (OSe) compounds as potential anticancer agents. New derivatives (HB178, HB179, HB181, HB183, HB208, HB209, and HB210) were synthesized and screened for cytotoxicity against eight cancer cell lines (including HN9, FaDu, MCF7, A375, HEPG2, HuH7, A549, and HCT

Identifiers

PMID41635496
PMCPMC12862577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.