Evidence map›Paper›PMID 41635490›Full record

ArticleBJUI compass2026

Risk factors of negative prostate biopsies: A CHAID decision tree analysis.

Pierre Allainguillaume, Coralie Uthe-Spencker, Laura Larnaudie, Mathilde Sibony, Anthony Kanbar, Albert Semaan, Nicolas Barry Delongchamps, Michael Peyromaure, Julien Anract

Abstract read
In one paragraph

Article in BJUI compass, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pierre AllainguillaumeUrology Department Cochin Hospital, APHP Paris France.ORCID https://orcid.org/0009-0006-8829-2176
Coralie Uthe-SpenckerUrology Department Cochin Hospital, APHP Paris France.
Laura LarnaudiePathology Department Cochin Hospital Paris France.
Mathilde SibonyPathology Department Cochin Hospital Paris France.
Anthony KanbarUrology Department Cochin Hospital, APHP Paris France.
Albert SemaanUrology Department Cochin Hospital, APHP Paris France.
Nicolas Barry DelongchampsUrology Department Cochin Hospital, APHP Paris France.ORCID https://orcid.org/0000-0001-5827-9567
Michael PeyromaureUrology Department Cochin Hospital, APHP Paris France.
Julien AnractUrology Department Cochin Hospital, APHP Paris France.ORCID https://orcid.org/0009-0006-7580-1066

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to perform a risk analysis of any prostate cancer (Pca) and of clinically significant prostate cancer (csPCa) in a contemporary cohort of prostatic biopsies. Materials and Methods: We conducted a retrospective analysis of patients who underwent prostate biopsies in our centre between December 2020 and December 2022. We calculated Pca and csPCa rate (ISUP grade ≥2). Univariate and multivariate regression models were constructed to assess independent predictive factors for Pca and csPCa. We used Results: We included 255 patients in the analysis, of whom 69.8% had positive biopsies for Pca and 36.9% for csPCa. Multivariate analysis found PSA density (PSAd) (OR = 1.001) (1.000; 1.001), PIRADS score (OR = 1.393) (1.234; 1.571) as independent predictive factors of csPCa. For the detection of any PCa, CHAID analysis revealed that patients with PIRADS score ≤4 doubled the risk of negative biopsies (from 22.6% to 54.3%) when the prostate volume was >46 mL. Conclusion: For patients with a PIRADS ≤4, a large prostate volume (>46 mL) was a predictor of negative biopsies, independently of PSAd. MRI interpretation and targeting in these patients should therefore be performed with particular caution.

Indexed as

prostate biopsiesprostate cancerrisk factors

Identifiers

PMID41635490
PMCPMC12863419

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.