ReviewFrontiers in transplantation2025
Liver transplant and impact on cerebral autoregulation: a systematic scoping review.
Review in Frontiers in transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Cerebral autoregulation (CA)-the brain's ability to maintain stable cerebral blood flow (CBF) despite changes in mean arterial pressure (MAP)-may be disrupted during orthotopic liver transplantation (OLT) due to profound metabolic, inflammatory, and hemodynamic alterations. Such impairment could increase the risk of cerebral hypoperfusion or hyperemia, yet its perioperative evolution and clinical implications remain unclear. This systematic scoping review aimed to synthesize current evidence on CA monitoring during OLT and to identify methodological gaps and potential clinical applications. Methods: A systematic scoping review was conducted according to Joanna Briggs Institute (JBI) guidelines. Studies including adult patients undergoing OLT with quantitative perioperative CA assessment were identified across PubMed, Embase, Scopus, Web of Science, and Medline. Results: Six studies ( Conclusions: CA appears to be dynamically affected during OLT, particularly in acute liver failure, but evidence remains limited by methodological heterogeneity and small sample sizes. Standardized, prospective studies are needed to clarify the role of CA monitoring and to determine whether individualized blood pressure management could improve neurological outcomes.
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