ArticleCureus2026
Quality of Life Among Head and Neck Cancer Patients at a Tertiary Care Hospital in Assam, India: A Mixed-Methods Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe physical, psychological, and social functioning of patients with head and neck cancer (HNC) is profoundly affected, resulting in considerable challenges to their quality of life (QoL). This mixed-method study used both quantitative and qualitative methods to evaluate the QoL of HNC patients who were attending a tertiary cancer centre in Assam. MATERIALS AND
methodsEighty adult HNC patients who were seen in the State Cancer Institute's outpatient department in Guwahati participated in a cross-sectional mixed-method study. Quantitative data were collected using the Assamese versions of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 (EORTC QLQ-C30) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Head and Neck 43 (EORTC QLQ-H&N43) questionnaires. Relationships between the functional and symptom domains and overall QoL were investigated using correlation analysis. To explore patients' experiences related to physical, emotional, social, and role functioning, semi-structured interviews were conducted. Integration of quantitative and qualitative findings ensured methodological rigour.
resultsWhile emotional and role functioning were significantly compromised, cognitive functioning displayed the highest mean functional score. Emotional (45.3%) and role functioning (54.1%) showed lower scores, while physical (64.4%) and social functioning (52.6%) demonstrated moderate limitation. Cognitive functioning was the highest-scoring domain (75.3%). The most affected symptom domains included fatigue (56.2%), financial difficulty (55.2%), dry mouth (55.9%), sticky saliva (53.2%), social contact problems (53.7%), appetite loss (44.8%), and pain (41.3%). The H&N43's recently measured domains of sexual desire, neck/skin symptoms, and fear of recurrence also demonstrated a moderate impact. Persistent pain, difficulty swallowing, reliance on food, speech impairment, social disengagement due to disfigurement, and severe emotional distress were all highlighted in the qualitative findings. Many patients suffered from financial toxicity, strained family ties, and diminished work capacity.
conclusionIn the social, emotional, physical, and financial spheres, HNC substantially lowers QoL. When paired with psychological distress and financial stress, symptom burden, particularly xerostomia, swallowing issues, and exhaustion, strongly predicts lower overall QoL. Improving survivorship outcomes requires comprehensive multidisciplinary care that addresses financial counselling, psychological support, and symptom management.
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