Evidence map›Paper›PMID 41635362›Full record

ArticleCureus2026

Vanishing Bile Duct Syndrome as a Rare Complication of Classic Hodgkin's Lymphoma: A Case Report and Literature Review.

Jody W Tai, Vivek D Shah, Rhett L Harmon, Shaun Chandna, Jessica Yan, Payman Fathizadeh, Simon Beaven, Deepthi Karunasiri, Phyllis Kim

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jody W TaiInternal Medicine, Olive View University of California Los Angeles Medical Center, Los Angeles, USA.
Vivek D ShahHematology and Oncology, Olive View University of California Los Angeles Medical Center, Los Angeles, USA.
Rhett L HarmonInternal Medicine, Olive View University of California Los Angeles Medical Center, Los Angeles, USA.
Shaun ChandnaGastroenterology, Olive View University of California Los Angeles Medical Center, Los Angeles, USA.
Jessica YanHematology and Oncology, Olive View University of California Los Angeles Medical Center, Los Angeles, USA.
Payman FathizadehPathology, Olive View University of California Los Angeles Medical Center, Los Angeles, USA.
Simon BeavenGastroenterology, Olive View University of California Los Angeles Medical Center, Los Angeles, USA.
Deepthi KarunasiriPathology, Olive View University of California Los Angeles Medical Center, Los Angeles, USA.
Phyllis KimHematology and Oncology, Olive View University of California Los Angeles Medical Center, Los Angeles, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vanishing bile duct syndrome (VBDS) is an acquired condition of progressive intrahepatic bile duct loss, resulting in severe cholestasis. Here, we present a case of VBDS in a patient with newly diagnosed classic Hodgkin's lymphoma (cHL). Our patient presented with cholestatic liver test elevations, including bilirubin and alkaline phosphatase. Liver biopsy confirmed the paucity of bile ducts and did not show involvement by lymphoma. Though the exact pathophysiology is unclear, it is postulated to be driven by cytokine release and T-lymphocyte cell dysregulation. Our patient has made a remarkable, albeit incomplete, liver recovery with cHL-directed treatment. Given the poor prognosis and higher mortality rate of VBDS, a multidisciplinary approach involving oncology, hepatology, and prompt initiation of dose-adjusted chemotherapy is imperative.

Indexed as

abvd chemotherapyacute liver failure (alf)classic hodgkin lymphomaparaneoplastic phenomenonvanishing bile duct syndrome

Identifiers

PMID41635362
PMCPMC12863710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.