ArticleCureus2026
From Needle to Necrosis: A Case Report on Nicolau Syndrome.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- An Unusual Presentation of Nicolau Syndrome in the Upper Limb: A Case Report from Northern Ecuadorian Amazonia.Journal of clinical medicine · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicolau syndrome is a rare but dreaded complication that can occur after a routine injection. It causes pain followed by ischemia and necrosis of the area, sometimes leading to serious and potentially life-threatening complications. Various drugs have been attributed to causing this, but only after being administered via an injection. What begins as pain and discoloration of the skin over the injection site quickly takes a sinister turn to become ischemic, ultimately leading to tissue necrosis. As the practice of administering injections is a major part of general medical practice, it becomes crucial to understand the inciting factors and know the potential complications of this otherwise harmless procedure. Here we report a 51-year-old daily wage worker who had pain followed by dark discoloration and ultimately necrosis and ulceration following an intramuscular injection of diclofenac. This case report elaborates on various causes of Nicolau syndrome, the clinical presentations and treatment options of this disorder.
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Registered trials
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