ArticleAdvances in radiation oncology2025
Leveraging High-Fidelity Mode for Improved Online Adaptive Stereotactic Accelerated Partial Breast Treatment Efficiency.
Article in Advances in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Dosimetric evaluation of Ethos 2.0 high-fidelity mode for single-isocenter SRS.Journal of applied clinical medical physics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Cone beam computed tomography guided online adaptive radiation therapy (OART) for stereotactic accelerated partial breast irradiation (APBI) can help mitigate the effects of interfraction lumpectomy bed variation. However, OART leads to a prolonged treatment time due to daily reoptimization of the treatment plan, potentially increasing patient discomfort and intrafraction variation. Here, we investigate the feasibility of using a stereotactic radiation therapy optimization feature, high-fidelity (HF) mode, through an in silico analysis of the entire APBI OART session. Methods and Materials: This retrospective in silico institutional review board-approved study included 25 patient data sets; 10 training patients allowed for iterative tuning of an HF planning strategy aiming to reduce optimization time with comparable plan quality to our previous non-HF planning strategy. Five OART treatment fractions were emulated for the remaining 15 patients in a virtual treatment planning and delivery system using both templates (with/without HF), resulting in the analysis of 330 validation cohort plans, including reference/nonadaptive/adaptive plans (initial plan/recalculated initial plan/reoptimized plan). Dose-volume-histogram metrics, optimization times, and patient-specific quality assurance results were compared with/without HF via the Wilcoxon paired test. Results: HF adaptive planning resulted in improved per-fraction breast V100%/50% (0.2%/3.3%), Ribs D0.01cc (0.2 Gy), and Paddick conformity/gradient indices (0.01/0.17), but led to marginally inferior planning target volume V100% (0.2%) and lung V30% (0.2%) compared to non-HF ( Conclusions: This work demonstrates that leveraging Ethos v2.0 HF mode may significantly improve stereotactic OART treatment efficiency for volumetric modulated arc therapy APBI, with >50% reduction in optimization time observed while maintaining plan quality on a nonclinical system, potentially leading to reduced patient discomfort and mitigated intrafraction variations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.