ArticleDiagnostic and interventional radiology (Ankara, Turkey)2026
Microvascular dysfunction in patients with transthyretin cardiac amyloidosis evaluated by 13N-ammonia positron emission tomography-computed tomography: is it an early marker of the disease?
Aristóteles Neto, Caio Cafezeiro, Bruno Bueno, Cristhian Espinoza Romero, Vitor Emer Rosa, Viviane Hotta, Camila de Godoi Carneiro, Carlos Rochitte, Vagner Madrini, Jose Soares and 5 more
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In one paragraphArticle in Diagnostic and interventional radiology (Ankara, Turkey), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
Aristóteles NetoHeart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-9524-0255 Caio CafezeiroHeart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-5960-2952 Bruno BuenoHeart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-6721-7779 Cristhian Espinoza RomeroHeart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-0191-7358 Vitor Emer RosaHeart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-6521-2870 Viviane HottaHeart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-9236-3815 Camila de Godoi CarneiroDepartment of Radiology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, Brazil.ORCID 0000-0002-6547-398X Carlos RochitteHeart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-4505-3344 Vagner MadriniHeart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-1116-6554 Jose SoaresHeart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-2419-081X William ChalelaHeart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-3751-0728 Marcos LimaDepartment of Radiology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, Brazil.ORCID 0009-0004-7358-776X Carlos BuchpiguelDepartment of Radiology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, Brazil.ORCID 0000-0003-0956-2790 Edward MillerMedicine and Radiology in the Section of Cardiovascular Medicine in Yale New Heaven Hospital, Connecticut, United States.ORCID 0000-0002-2156-5962 Fabio FernandesHeart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0009-0006-6462-3196 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
purposeTo evaluate coronary microvascular function using 13N-ammonia positron emission tomography/ computed tomography in individuals with pathogenic
methodsWe evaluated microvascular impairment by measuring CFR in 20 patients with and 20 patients without cardiac involvement due to TTR amyloidosis (ATTR), all presumed to be free from epicardial coronary artery disease and carrying
resultsThe study revealed a significantly reduced mean global CFR in the cardiac involvement group (1.849 ± 0.379 vs. 2.952 ± 0.7,
conclusionIn patients with ATTR CA, coronary microvascular dysfunction emerges as a clinically relevant marker of cardiac involvement, even in the absence of structural abnormalities or obstructive coronary disease. CLINICAL SIGNIFICANCE: CFR assessment may aid in diagnostic suspicion, risk stratification, and understanding of angina symptoms in this population.
Indexed as
Amyloid Neuropathies, FamilialMicrovesselsPositron Emission Tomography Computed TomographyAgedAmmoniaBiomarkersCoronary CirculationCoronary VesselsFemaleHumansMaleMiddle AgedNitrogen RadioisotopesSensitivity and SpecificityAmmoniaBiomarkersNitrogen-13Nitrogen RadioisotopesAmyloidosiscoronary arteriesmicrovascular blood flow
Identifiers
PMID41635189
PMCPMC13530596
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