ArticleMacromolecular bioscience2026
Dynamic Gelatin Hydrogels Crosslinked by Dithiolane-Norbornene Click Chemistry.
Article in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Scalable one-step synthesis of gelatin-dithiolane for neural tissue engineering.Journal of materials chemistry. B · 2026Article
- Dynamic Gelatin Hydrogels Crosslinked by Dithiolane-Norbornene Click Chemistry.Macromolecular bioscience · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
Hydrogels prepared from gelatin are ideal for mimicking the extracellular matrix (ECM) owing to their inherent cell-adhesive and protease-labile peptide sequences. While gelatin is highly water-soluble, it does not form the triple-helical structure. As a result, physically crosslinked gelatin-based hydrogels are only stable at low temperatures, precluding their use in 3D cell culture. Gelatin-methacryloyl (GelMA) and gelatin-norbornene (GelNB) have been developed to enable the stable crosslinking of gelatin-based hydrogels via chain-growth or step-growth photopolymerization. However, most gelatin-based hydrogels lack dynamically tunable properties unless macromers with dynamically crosslinkable motifs are used. Here, we integrate GelNB with dithiolane-containing crosslinker poly(ethylene glycol)-tetra-lipoic acid (PEG4LA)-for modular photo-crosslinking of GelNB into hydrogels under cytocompatible light exposure (365 nm, 5 mW/cm
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