ArticleParasites & vectors2026
Efficacy evaluation of a new oral chewable tablet containing fluralaner, moxidectin, and pyrantel (BRAVECTO
Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Field study evaluating the efficacy of a combination formulation of fluralaner with moxidectin and pyrantel (BRAVECTOParasites & vectors · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBroad-spectrum combination products with efficacy against endo- and ectoparasites offer the potential to optimize owner adherence to expert recommendations for canine antiparasitic treatments. In the development program for a chewable tablet containing fluralaner, moxidectin, and pyrantel, a non-terminal study design was implemented to determine anthelminthic efficacy. Four laboratory studies assessed the efficacy of this investigational veterinary product (IVP) against adult hookworms and adult Toxascaris leonina.
methodsIn four single-site, non-terminal dose confirmation studies, dogs were inoculated with third-stage larvae of Uncinaria stenocephala (Studies 1 and 2), Ancylostoma caninum (Study 3), or larvated eggs of T. leonina (Study 4). Using fecal egg counts (FECs) from those infections, dogs were ranked and randomized to groups (Studies 1, 3, and 4, 10 per group; Study 2, 8 per group and treated once orally, on day 0, with the minimum recommended IVP dose (fluralaner 10 mg/kg, moxidectin 0.025 mg/kg, pyrantel 5 mg/kg) (BRAVECTO
resultsAdequacy of infection was shown in all studies. Relative to the control groups, statistically significant reductions in mean worm counts were found in IVP-treated groups in Studies 1, 2, 3, and 4 (99.8%, P < 0.0001; 100%, P = 0.0002; 100%, P < 0.0001; and 99.4%, P < 0.0001, respectively). All control dogs had positive FECs until the DDW treatment, while no eggs were detected after day 0 in 36 of the 38 IVP-treated dogs. Findings from copro-PCR and antigen-ELISA were consistent with and confirmatory of the conclusions from worm counts and FECs.
conclusionsA single, orally administered dose of this chewable tablet formulation is effective in treating canine infections with adult hookworms (U. stenocephala, A. caninum) and T. leonina. Non-terminal studies present a valid means of determining the efficacy of anthelmintic treatments for these canine intestinal parasites.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.