ArticleLipids in health and disease2026
Associations of insulin-like growth factor 1 and IGF binding proteins 2 and 3 with lipids in toddlers.
Article in Lipids in health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02907502 (Effects of Milk Protein Intake in Young Children on Early Growth and Later Obesity Risk), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Effects of Milk Protein Intake in Young Children on Early Growth and Later Obesity Risk: a Multicentre Randomized Clinical Trial
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11 authors.
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Abstract
BACKGROUND AND
objectivesThe insulin-like growth factor (IGF) axis is postulated to influence early-life adipocyte activity and lipolysis. We investigated whether IGF-1 and IGF-binding proteins (IGFBP-2, IGFBP-3) are associated with the lipids of healthy toddlers.
methodsData were collected during the Toddler Milk Intervention trial to test the effect of milk protein on growth in the second year of life in Germany and Spain. Any blood values for IGF-1, IGFBP-2, IGFBP-3, low- and high-density lipoprotein cholesterol (LDL-C, HDL-C), total cholesterol (TC) and triglycerides (TG) were available at 12 and 24 months from 881 to 775 toddlers, respectively. These blood parameters were available from 444 children at both time points. Mixed intercept linear models adjusted for sex, fasting duration, country, and body mass index (BMI) were used to assess the associations between the IGF axis and lipids.
resultsBMI was 17.0 ± 1.4 kg/m
conclusionThe IGF axis is weakly associated with circulating lipids. IGF-1 and its binding proteins seem to have a limited impact on lipid profiles of toddlers.
trial registrationClinical trial registration number: NCT02907502, 26.04.2016.
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