ArticleBMC neurology2026
A notable case of primary progressive freezing of gait associated with parietal cortical atrophy.
Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFreezing of gait (FOG) is a symptom that occurs in Parkinson’s disease (PD) and various other gait disorders. Primary progressive freezing of gait (PPFG) disorder is a rare clinical syndrome in which FOG persists for at least three years without any other clinical symptoms. We report a patient with long-lasting isolated FOG accompanied by marked parietal cortical atrophy to explore its potential pathophysiological significance. CASE PRESENTATION: A 55-year-old man presented with a one-year history of FOG and recurrent unprovoked falls. Neurological examinations revealed FOG without signs of parkinsonism. While dopamine transporter (DAT) imaging showed normal uptake, brain magnetic resonance imaging (MRI) demonstrated marked bilateral parietal lobe atrophy without brainstem atrophy. Five years later, FOG persisted with mild parkinsonism, consistent with the diagnosis of PPFG. Follow-up MRI and DAT imaging revealed no interval changes. Single-case voxel-based morphometry demonstrated reduced volume in the right superior parietal lobe and left superior occipital gyrus, and neuropsychological testing indicated preserved cognition across all domains.
conclusionThis case illustrates a rare presentation of long-standing isolated FOG associated with localized parietal cortical atrophy. These findings suggest that involvement of the parietal cortex may contribute to the pathophysiology of FOG.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.