Evidence map›Paper›PMID 41634612›Full record

ArticleBMC medical imaging2026

Pre-treatment subventricular zone perfusion asymmetry predicts vertical recurrence in glioblastoma.

Minchul Kim, Yunseo Choi, Jung Hyun Park, Chul-Kee Park, Sung Hye Park, Seung Hong Choi, Kyu Sung Choi

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Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Minchul KimDepartment of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Yunseo ChoiCHA University School of Medicine, Pocheon, South Korea.
Jung Hyun ParkDepartment of Radiology, Seoul Metropolitan Government, Boramae Medical Center, Seoul National University, Seoul, South Korea.
Chul-Kee ParkDepartment of Radiology, Seoul National University College of Medicine, Seoul, South Korea.
Sung Hye ParkDepartment of Radiology, Seoul National University College of Medicine, Seoul, South Korea.
Seung Hong ChoiDepartment of Radiology, Seoul National University Hospital, Seoul, South Korea.
Kyu Sung ChoiDepartment of Radiology, Seoul National University Hospital, Seoul, South Korea. kyuchoi86@gmail.com.

Funding

Ministry of Health and Welfare No. RS-2024-00439549National Research Foundation of Korea No. RS-2023-00251022Samsung Hospital & Sungkyunkwan University KBSMC-SKKU Future Clinical Convergence Academic Research ProgramSeoul National University Hospital No. 04-2023-2050
6 · The paper itself

Abstract

backgroundThe subventricular zone (SVZ) has been involved in glioblastoma (GBM) progression; however, the detection of mutated cells in the SVZ via imaging remains unclear. This study aimed to identify the detection of mutated stem cells in the SVZ using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), which was utilized to investigate changes in the SVZ in patients with recurrent GBM after gross total resection (GTR). MATERIALS &

methodsThis study used presurgical DCE–MRI to assess 63 patients with recurrent GBM after GTR (mean age = 58 ± 14 years). Regions of interest in the ipsilesional and contralesional SVZ were identified. The volume transfer constant (Ktrans) and plasma volume fraction (Vp) values, including changes in the histograms, were assessed.

resultsThe skewness and kurtosis of Vp values were significantly lower in ipsilesional SVZ and lateral ventricle around the caudate nucleus compared with the contralesional SVZ (p = 0.04 and 0.02, respectively). No significant difference was observed in the mean (p = 0.81 ~ 0.88) and median (p = 0.31 ~ 0.46) of the Vp values as well as Ktrans.

conclusionThese results indicate significantly lower skewness and kurtosis of Vp values in the ipsilesional SVZ compared with the contralesional SVZ, revealing that these Vp histogram parameters may be associated with “vertical recurrence” in GBM after GTR. ADVANCES IN KNOWLEDGE: We discovered latent DCE alteration in ipsilesional SVZ in patients with GBM recurrence after GTR.

Indexed as

Brain NeoplasmsGlioblastomaLateral VentriclesNeoplasm Recurrence, LocalAdultAgedContrast MediaDynamic Contrast Enhanced Magnetic Resonance ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPerfusion Magnetic Resonance ImagingContrast MediaBlood–brain barrier imagingDynamic contrast-enhanced MRIGlioblastoma recurrenceHistogram analysisSubventricular zone

Identifiers

PMID41634612
PMCPMC12958514

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.