Evidence map›Paper›PMID 41634595›Full record

ArticleBMC plant biology2026

Genome-wide identification and characterization of the RPA gene family in maize.

Xiaoling Zhang, Caihong Sun, Bingying Li, Qinli Yang, Huanli Li, Huanyang Zhang, Hongli Li, Yonghong Zhu, Jing Li, Xiaoxia Shangguan

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Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Xiaoling ZhangCotton Research Institute, Shanxi Agricultural University, Yuncheng, 044000, China. lindaisclver@126.com.
Caihong SunCollege of Agriculture, Shanxi Agricultural University, Taigu, 030801, China.
Bingying LiCollege of Agriculture, Shanxi Agricultural University, Taigu, 030801, China.
Qinli YangCotton Research Institute, Shanxi Agricultural University, Yuncheng, 044000, China.
Huanli LiCotton Research Institute, Shanxi Agricultural University, Yuncheng, 044000, China.
Huanyang ZhangCotton Research Institute, Shanxi Agricultural University, Yuncheng, 044000, China.
Hongli LiCollege of Agriculture, Shanxi Agricultural University, Taigu, 030801, China.
Yonghong ZhuCotton Research Institute, Shanxi Agricultural University, Yuncheng, 044000, China.
Jing LiCotton Research Institute, Shanxi Agricultural University, Yuncheng, 044000, China.
Xiaoxia ShangguanCotton Research Institute, Shanxi Agricultural University, Yuncheng, 044000, China. sgxx74@126.com.

Funding

Doctoral Research Grant Program from the Cotton Research Institute of Shanxi Agricultural University SBSJJ2023-01Outstanding Young Doctor Award at Shanxi Agricultural University 2023BQ22Shanxi Agricultural University Cotton Research Institute Innovation Development project SJJCX2023-04Shanxi Agricultural University Science and Technology Innovation Promotion Project CXGC2025040Shanxi Province doctoral graduates, PhD After the researchers to Jin work award funding research project SXBYKY2023024Shanxi Provincial Basic Research Project 202303021212083Subproject of Shanxi Science and Technology Major Program-Challenge-based Research Initiative 202201140601025-5-04
6 · The paper itself

Abstract

backgroundThe Replication Protein A (RPA) is a highly conserved heterotrimeric complex that binds single-stranded DNA and interacts with multiple proteins, playing essential roles in DNA replication, repair, and homologous recombination, thereby maintaining genome stability and supporting normal development. However, the specific members and functions of the RPA gene family remain uncharacterized in maize.

resultsIn this study, 13 ZmRPA members in maize were identified, which exhibited a wide range of protein lengths, from 86 to 876 amino acids. A phylogenetic analysis of these ZmRPA genes revealed their classification into three distinct subgroups: RPA1, RPA2, and RPA3. Notably, within each subgroup, the motifs of ZmRPA proteins were similar, although variations were observed among different subfamilies. An analysis of gene duplication events suggests that RPA genes have remained highly conserved in maize. Furthermore, the analysis of cis-elements indicated that RPA genes are associated with light-responsive, as well as plant growth and development. RNA-seq analysis revealed that some ZmRPA genes exhibited pronounced expression changes under cold and drought stresses, while the results of tissue-specific expression analysis showed that most ZmRPA genes were highly expressed in the actively dividing meristems and reproductive primordia. Protein interaction and yeast two-hybrid assays revealed that ZmRPA family members interact with each other to perform their biological functions.

conclusionsCollectively, these findings suggest that ZmRPA family subunits may play important roles in plant growth and development, as well as stress responses, by forming various types of heteromeric complexes through protein interactions. This study provides a comprehensive understanding of the RPA gene family in maize and will facilitate further effective characterization of the RPA genes.

Indexed as

Genes, PlantPlant ProteinsReplication Protein AZea maysGene Expression Regulation, PlantGenome, PlantMultigene FamilyPhylogenyPlant ProteinsReplication Protein AGene expressionGenome-wide identificationMaizeProtein-protein interactionRPA gene family

Identifiers

PMID41634595
PMCPMC12964672

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