ArticleAnimal biotechnology2026
Integrative metabolomic and transcriptomic analysis reveals stage-specific shifts in hepatic lipid metabolism of broiler chickens.
Article in Animal biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Conjugated Linoleic Acid Alleviates Hepatic Steatosis and Liver Damage in Estradiol-Induced FLHS Roosters by Reshaping Lipid Metabolism and Inhibiting the MAPK/NF-κB-Mediated Inflammation Cascade.Animals : an open access journal from MDPI · 2026Article
- Hepatic transcriptomic landscape of chicken reveals host responses to spotty liver disease.PloS one · 2026Article
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Authors and funding
8 authors.
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Abstract
Managing fat accumulation is a critical goal in the poultry industry, with the liver being the primary site for lipid metabolism in chickens. This study used non-targeted metabolomics to investigate dynamic changes in metabolite composition in chicken liver across five physiological stages. A total of 1121 metabolites were identified, with 749 and 372 detected in positive- and negative-ion modes, respectively. The regulation of hepatic lipolysis involves numerous metabolic pathways, making it a complex process. We performed trend analysis of lipid, carbohydrate and amino acid-related metabolites. Age exerted major effects on hepatic metabolism, significantly enriching pathways including alpha-linolenic acid metabolism, linoleic acid metabolism, steroid hormone biosynthesis, 2-oxocarboxylic acid metabolism and nicotinate and nicotinamide metabolism. Transcriptomic analysis identified 12 lipid-metabolism-related genes, showing a tendency of continuously increase. Potential functional genes influencing lipid metabolism-related pathways were identified through a comprehensive analysis of differential lipid-related metabolites and genes, including
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