Evidence map›Paper›PMID 41634526›Full record

ArticleTranslational stroke research2026

Transplantation of Skin-Derived Precursor Schwann Cells Ameliorates Secondary Brain Injury after ICH in Mice by Activating the PI3K/AKT/FOXO3a Signaling Pathway.

Yuqian Tang, Yan Song, Qiuwen Sun, Muyuan Tong, Yejing Zhang, Yan Chen, Junyi Sha, Chengbin Xue, Jiabing Shen, Aihong Li

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Article in Translational stroke research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuqian Tang *Department of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, PR China.
Yan Song *Department of Neurology, Nantong Hospital of Traditional Chinese Medicine, Nantong, 226000, PR China.
Qiuwen SunDepartment of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, PR China.
Muyuan TongDepartment of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, PR China.
Yejing ZhangDepartment of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, PR China.
Yan ChenDepartment of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, PR China.
Junyi ShaDepartment of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, PR China.
Chengbin XueResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, PR China. xue_chengbin@hotmail.com.
Jiabing ShenDepartment of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, PR China. shenjb0818@ntu.edu.cn.
Aihong LiDepartment of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, PR China. liaihongbox@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the therapeutic potential of skin-derived precursor Schwann cells (SKP-SCs) for secondary brain injury following intracerebral hemorrhage (ICH) and its underlying mechanisms. An ICH model was established in mice via intrastriatal autologous blood injection. SKP-SCs were administered intranasally 24 h post-ICH, with the AKT inhibitor GDC0068 used for intervention. Results demonstrated that transplanted SKP-SCs survived peri-hematomally, significantly improved short- and long-term neurological function, reduced brain tissue damage and neuronal apoptosis, preserved blood-brain barrier integrity, and suppressed microglial/macrophage activation and neutrophil infiltration. Mechanistically, SKP-SCs exerted neuroprotection by activating the PI3K/AKT/FOXO3a signaling pathway. In conclusion, intranasal SKP-SC transplantation alleviates ICH-induced deficits and secondary injury via this pathway, representing a promising therapeutic strategy during the acute phase following ICH.

Indexed as

Brain InjuriesCerebral HemorrhageForkhead Box Protein O3Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSchwann CellsSignal TransductionSkinAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLForkhead Box Protein O3FoxO3 protein, mousePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktIntracerebral hemorrhageNeuroinflammationPI3K/AKT/FOXO3a signaling pathwaySecondary brain injurySKP-SCs

Identifiers

PMID41634526

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.