SynthesisNeurosurgical review2026
Connectome-guided glioma resection: a systematic review of white matter tract preservation and postoperative neurocognition.
Synthesis in Neurosurgical review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- When Surgical Innovation Outpaces Evidence: Does Modern Maximal Resection Require Re-Evaluation of Postoperative Radiotherapy in Glioblastoma?Medical sciences (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Connectome-guided glioma surgery integrates diffusion tractography and functional network mapping to optimize maximal safe resection while minimizing cognitive morbidity.To synthesize outcome-based evidence evaluating the impact of connectome- and tractography-guided glioma resections on postoperative neurocognition, white matter tract preservation, and oncologic extent of resection (EOR). Following PRISMA-2020 guidelines, we systematically reviewed studies (2017–2025) reporting clinical outcomes after connectome- or tractography-guided glioma surgery. Data included study design, technique, number of patients, and effect sizes. Random-effects meta-analyses (DerSimonian–Laird) pooled odds ratios (OR) and 95% confidence intervals (CIs). Twenty-four studies (n ≈ 1,850) were included. Connectome-guided surgery is associated with fewer permanent postoperative neurocognitive deficits (pooled OR = 0.55, 95% CI 0.40–0.75; I² = 35%), improved white matter tract preservation (pooled OR = 1.25, 95% CI 1.10–1.42; I² = 40%), and maintained or improved EOR (pooled OR = 1.30, 95% CI 1.05–1.60; I² = 29%). Connectome-based surgical planning is associated with improved functional outcomes, while maintaining oncologic efficacy. These results support the adoption of individualized connectomic strategies as a standard in modern neuro-oncological practice.
Indexed as
Identifiers
41634470What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.