Evidence map›Paper›PMID 41634415›Full record

ArticleNature genetics2026

Childhood brain tumors instruct cranial hematopoiesis and immunotolerance.

Elizabeth Cooper, David A Posner, Colin Y C Lee, Linda Hu, Sigourney Bonner, Jessica T Taylor, Oscar Baldwin, Rocio Jimenez-Guerrero, Katherine E Masih, Katherine Wickham Rahrmann and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Elizabeth CooperCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK. Elizabeth.Cooper@cruk.cam.ac.uk.ORCID 0009-0008-4719-7820
David A PosnerDepartment of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Colin Y C LeeDepartment of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.ORCID 0000-0001-8380-4917
Linda HuCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Sigourney BonnerCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Jessica T TaylorCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID 0000-0001-8565-8589
Oscar BaldwinCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID 0009-0006-0269-7659
Rocio Jimenez-GuerreroCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Katherine E MasihCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID 0000-0002-0809-668X
Katherine Wickham RahrmannCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Jason EigenbroodCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID 0009-0002-9117-2782
Gina NgoCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Valar Nila Roamio FranklinCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Clive S D'SantosCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Richard MairCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID 0000-0001-8235-5689
Thomas SantariusAcademic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Claudia CravenAcademic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Ibrahim JallohAcademic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Julia Moreno VicenteCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID 0000-0002-1740-9350
Timotheus Y F HalimCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID 0000-0001-9773-0023
Li WangThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9510-6294
Arnold R KreigstienThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5742-2990
Brandon WainwrightFaculty of Health, Medical and Behavioral Sciences, Frazer Institute, University of Queensland, Brisbane, Queensland, Australia.
Fredrik J SwartlingDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-8460-4367
Javed KhanGenetics Branch, NCI, NIH, Bethesda, MD, USA.ORCID 0000-0002-5858-0488
Menna R ClatworthyDepartment of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.ORCID 0000-0002-3340-9828
Richard J GilbertsonCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK. Richard.Gilbertson@cruk.cam.ac.uk.ORCID 0000-0001-7539-9472

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent research has challenged a long-held view of the brain as an immune-privileged organ, revealing active immunosurveillance with therapeutic relevance. Using a new genetically engineered mouse model of ZFTA-RELA ependymoma, a childhood brain tumor, we characterized an immune circuit between the tumor and antigen-presenting hematopoietic stem and progenitor cells (HSPCs) in the skull bone marrow. The presentation of antigens by HSPCs to CD4

Indexed as

Brain NeoplasmsEpendymomaHematopoiesisImmune ToleranceAnimalsCD4-Positive T-LymphocytesCytokinesDisease Models, AnimalHematopoietic Stem CellsHumansMiceSkullT-Lymphocytes, RegulatoryCytokines

Identifiers

PMID41634415
PMCPMC12900635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.