SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Role of nutritional (PNI, CONUT) and inflammatory indices (SII) in predicting lymph node metastasis and prognosis of thyroid cancer: a systematic review and meta-analysis.
Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMarkers reflecting systemic inflammation and nutritional condition are now often applied in predicting cancer outcomes, yet their role in thyroid malignancies has not been clearly established. We reviewed the evidence in the literature on the role of Prognostic Nutritional Index (PNI), Controlling Nutritional Status Score (CONUT), and Systemic Immune-Inflammation Index (SII) in predicting lymph node metastasis (LNM), overall survival (OS), and disease-free survival (DFS) in thyroid cancer.
methodsTwo reviewers searched CENTRAL, Embase, PubMed, and Scopus databases till 24th August 2025 for relevant publications. A random-effects meta-analysis was conducted.
resultsThirteen studies were eligible. Combined results demonstrated that elevated SII was slightly but significantly correlated with increased risk of LNM (HR: 1.00; 95% CI: 1.00-1.01; I² = 93%). Results failed to change in the sensitivity analysis. Subgroup analysis based on location and histology indicated non-significant results while meta-regression did not identify any significant moderators. Pooled analysis indicated no significant association between low PNI and DFS (HR: 1.45 95% CI: 0.97, 2.18 I2 = 80%) and LNM (HR: 1.31 95% CI: 0.89, 1.92 I2 = 73%) in thyroid cancer patients. Meta-analysis also showed that high CONUT was associated with a tendency of worse DFS in thyroid cancer, but results were non-significant (HR: 3.25 95% CI: 0.99, 10.69 I2 = 86%). However, meta-analysis showed that high CONUT was significantly associated with worse OS (HR: 9.67 95% CI: 1.90, 49.25 I2 = 61%).
conclusionsLimited data suggest that high SII may be marginally associated with increased risk of LNM in thyroid cancer, the clinical significance of which is questionable. PNI was not found to be associated with LNM or DFS in thyroid cancer patients. High CONUT was associated with poor OS and a non-significant tendency for worse DFS in thyroid cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.