Evidence map›Paper›PMID 41634383›Full record

ArticleAnnals of hematology2026

The impact of the expression signatures of LncRNAs HBBP1 and XIST on the diagnostic significance of patients with β-Thalassemia.

Abdallah M Gameel, Shimaa Abdelsattar, Zeinab A Kasemy, Mai El-Sayad Abd El-Hamid, Eman Masoud Abd ElGayed, Basma M Abdelgawed, Amira Fathy El-Fiky, Mariam E Labib, Sabry M Abdelmageed, Mahmoud Ahmed El Hawy and 2 more

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Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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12 authors.

Abdallah M GameelClinical Pathology Department, National Cancer Institute, Cairo University, Kasr Al-Aini Street, Fom El Khalig Square, Cairo, 11796, Egypt. abdallah.mohamed@nci.cu.edu.eg.ORCID http://orcid.org/0000-0003-4632-015X
Shimaa AbdelsattarClinical Biochemistry and Molecular Diagnostics Department, National Liver Institute, Menoufia University, Menoufia, Egypt.ORCID http://orcid.org/0000-0002-3993-5378
Zeinab A KasemyDepartment of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Shebine Elkoum, Egypt.
Mai El-Sayad Abd El-HamidPediatrics Department, Faculty of medicine, Menoufia University, Menoufi, Egypt.
Eman Masoud Abd ElGayedMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Basma M AbdelgawedFaculty of medicine, Menoufia National University, Menoufia, Egypt.
Amira Fathy El-FikyPediatrics Department, Faculty of medicine, Menoufia University, Menoufi, Egypt.
Mariam E LabibMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Sabry M AbdelmageedClinical Biochemistry and Molecular Diagnostics Department, National Liver Institute, Menoufia University, Menoufia, Egypt.
Mahmoud Ahmed El HawyPediatrics Department, Faculty of medicine, Menoufia University, Menoufi, Egypt.
Yasmin MohsenClinical Pathology Department, National Liver Institute, Menoufia University, Menoufia, Egypt.
Hanan M BedairClinical Pathology Department, National Liver Institute, Menoufia University, Menoufia, Egypt.ORCID http://orcid.org/0000-0002-2229-3129

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-thalassemia is an inherited blood disorder with long-term associated complications. The purpose of this study was to evaluate the clinical significance of the lncRNA-HBBP1 and lncRNA-XIST expression profiles in the diagnosis of β-thalassemia patients. One hundred children patients with β-thalassemia participated in this case-control study: 50 patients diagnosed as Beta Thalassemia Major (β-TM) and 50 patients diagnosed as Beta Thalassemia Intermedia (β-TI) groups. Furthermore, there were 50 children as healthy control group. Assessment of both genes' expression was performed by RT-qPCR. The findings displayed that both lncRNA-HBBP1 and lncRNA-XIST were highly expressed within the β-TM group than in the β-TI and the control groups (P < 0.001 for both). The lncRNA-HBBP1 and lncRNA-XIST expression were significantly higher in β-thalassemia patients presented with jaundice, thalassemia facies, or organomegaly (p < 0.001 for all). In addition, lncRNA-XIST expression was significantly higher in β-thalassemia patients with splenectomy (p = 0.002). Spearman correlation revealed that the expression of both genes was significantly correlated with HbF % in β-TM and β-TI groups (p < 0.001 for both). Based on the ROC curve analysis, the sensitivity of lncRNA-HBBP1 and lncRNA-XIST for discriminating the β-TM group from the β-TI group was 82% and 80%, respectively. Collectively, the examined lncRNAs could offer novel biomarkers for β-thalassemia disorder once confirmed in extensive upcoming investigations.

Indexed as

beta-ThalassemiaGene Expression RegulationRNA, Long NoncodingAdolescentCase-Control StudiesChildChild, PreschoolFemaleFetal HemoglobinHumansMaleFetal HemoglobinRNA, Long NoncodingLncRNA-HBBP1LncRNA-XISTRT-qPCRΒ-thalassemia

Identifiers

PMID41634383
PMCPMC12868124

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.