Evidence map›Paper›PMID 41634380›Full record

ArticleEMBO reports2026

SIRT4 regulates antiviral and autoimmune responses by promoting cGAS-mediated signaling pathways.

Bo Yang, Yanjie Zhang, Saiyu Wang, Yufei Wu, Zilu Diao, Qunmei Zhang, Chen Lu, Mengyang Shen, Xuewei Zhang, Shujun Ma and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bo Yang *Department of Rehabilitation Medicine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.ORCID 0000-0002-0501-3201
Yanjie Zhang *Xinxiang Key Laboratory of Inflammation and Immunology, School of Medical Technology, Xinxiang Medical University, Xinxiang, China.
Saiyu Wang *Xinxiang Key Laboratory of Inflammation and Immunology, School of Medical Technology, Xinxiang Medical University, Xinxiang, China.
Yufei WuXinxiang Key Laboratory of Inflammation and Immunology, School of Medical Technology, Xinxiang Medical University, Xinxiang, China.
Zilu DiaoXinxiang Key Laboratory of Inflammation and Immunology, School of Medical Technology, Xinxiang Medical University, Xinxiang, China.
Qunmei ZhangClinical Laboratory, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.
Chen LuXinxiang Key Laboratory of Inflammation and Immunology, School of Medical Technology, Xinxiang Medical University, Xinxiang, China.
Mengyang ShenXinxiang Key Laboratory of Inflammation and Immunology, School of Medical Technology, Xinxiang Medical University, Xinxiang, China.
Xuewei ZhangDepartment of Rehabilitation Medicine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Shujun MaHenan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Chunsheng YangDepartment of Rehabilitation Medicine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Jinyong PeiXinxiang Key Laboratory of Inflammation and Immunology, School of Medical Technology, Xinxiang Medical University, Xinxiang, China.
Hongxia XingDepartment of Rehabilitation Medicine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Yinming LiangHenan Key Laboratory of Immunology and Targeted Drug, Xinxiang Medical University, Xinxiang, China. yinming.liang@gris.org.cn.ORCID 0000-0001-9174-4037
Jie WangDepartment of Rehabilitation Medicine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China. jiewang618@xxmu.edu.cn.ORCID 0000-0003-4495-8862

Funding

111 Plan | Overseas Expertise Introduction Project for Discipline Innovation D20036Key Scientific and Technological Projects of Henan Province 232102310154MOST | National Natural Science Foundation of China (NSFC) 32170871 and 82371759| Natural Science Foundation of Henan Province (Henan Natural Science Foundation) 222300420064,252300421249Program for Science and Technology Innovation Talents in higher education of Henan Province 23HASTIT050Zhongyuan Academician Fund from Henan Province C24185
6 · The paper itself

Abstract

Cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) is a critical cytosolic DNA sensor, whose activity can be regulated by acetylation. Here, we show that nicotinamide adenine dinucleotide (NAD

Indexed as

AutoimmunityNucleotidyltransferasesSignal TransductionSirtuinsAcetylationAnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseExodeoxyribonucleasesHEK293 CellsHerpes SimplexHerpesvirus 1, HumanHumansImmunity, InnateInterferon Type ILeukocytes, MononuclearcGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseExodeoxyribonucleasesInterferon Type INucleotidyltransferasesPhosphoproteinsSirtuinsthree prime repair exonuclease 1AcetylationAntiviral Innate Immune ResponsesAutoimmune ResponsesDNA VirusSignal Transduction

Identifiers

PMID41634380
PMCPMC12979681

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.