Evidence map›Paper›PMID 41634357›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Prevalence and safety of diazoxide in the neonatal intensive care unit.

Lucas C Collins, Katherine B Daniel, Veeral N Tolia, Pratik Parikh, Keyaria D Gray, Rachel G Greenberg

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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lucas C CollinsDuke University School of Medicine, Durham, NC, USA.
Katherine B DanielDuke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0003-1151-2872
Veeral N ToliaPediatrix Center for Research, Education, Quality and Safety, Sunrise, FL, USA.
Pratik ParikhPediatrix Center for Research, Education, Quality and Safety, Sunrise, FL, USA.
Keyaria D GrayDepartment of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
Rachel G GreenbergDepartment of Pediatrics, Duke University School of Medicine, Durham, NC, USA. rachel.greenberg@duke.edu.ORCID http://orcid.org/0000-0003-4156-8543

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDiazoxide is used to treat infants with persistent hyperinsulinemic hypoglycemia. While recent studies have highlighted its adverse effects and variable usage, further characterization is needed. We report the demographic and clinical characteristics of infants exposed to diazoxide across NICUs. STUDY

designCohort study including infants born 24-41 weeks gestation and admitted to 345 NICUs from 2017-2022. Comparisons were made between hypoglycemic infants exposed to diazoxide and those not, collecting data on adverse events and additional therapies.

resultsAmong 545,065 infants, 22% were diagnosed with hypoglycemia, and 0.16% were exposed to diazoxide. Diazoxide use remained stable, with variability across NICUs (0-16%). Among infants exposed to diazoxide, 13% started new diuretic courses, 10% had new oxygen supplementation, and 3% needed ventilator support.

conclusionsDiazoxide use in NICUs has remained stable over time. Although some infants received additional therapies, namely diuretics, most were able to discontinue diazoxide prior to discharge.

Indexed as

Congenital HyperinsulinismDiazoxideDiureticsFemaleHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMalePrevalenceDiazoxideDiuretics

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.