Evidence map›Paper›PMID 41634350›Full record

ReviewBJC reports2026

Implementing mainstream germline genetic testing in breast cancer across Europe.

Eduard Pérez-Ballestero, Sagal Ahmed Shire, Mateja Krajc, Arvīds Irmejs, Lenka Foretová, Sophie Frank, Tiina Kahre, Thomas van Overeem Hansen, Linetta Koppert, Anna Lena Burgemeister and 4 more

Abstract readReview
In one paragraph

Review in BJC reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Bridging the gap: integrating hereditary cancer into precision oncology.European journal of human genetics : EJHG · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eduard Pérez-BallesteroMedical Oncology Department, Hospital Vall d'Hebron, Vall d'Hebron Campus, Universitat Autònoma de Barcelona, Barcelona, Spain.
Sagal Ahmed ShireDepartment of Clinical Genetics, Sout West Thames Centre for Genomics, St. George's University Hospital, London, UK.
Mateja KrajcDepartment of Clinical Cancer Genetics, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Arvīds IrmejsPauls Stradins Clinical University Hospital, Riga, Latvia.
Lenka ForetováMasaryk Memorial Cancer Institute, Brno, Czech Republic.
Sophie FrankInstitut Curie, Paris, France.
Tiina KahreGenetics and Personalized Medicine Clinic, Tartu University Hospital, and Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Thomas van Overeem HansenDepartment of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Linetta KoppertErasmus Medical Center, Rotterdam, the Netherlands.
Anna Lena BurgemeisterMGZ-Medical Genetics Center, Munich, Germany.
Marc TischkowitzDepartment of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.
Judith BalmañaMedical Oncology Department, Hospital Vall d'Hebron, Vall d'Hebron Campus, Universitat Autònoma de Barcelona, Barcelona, Spain.
Svetlana Bajalica-LagercrantzDepartment of Oncology-Pathology, Karolinska Institutet, and Hereditary Cancer Unit, Department of Clinical Genetics and Genomics and Theme Cancer, Karolinska University Hospital, Stockholm, Sweden. svetlana.lagercrantz@ki.se.
ERN GENTURIS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The implementation of mainstream germline genetic testing in breast cancer patients has both benefits and challenges. Multiple aspects need to be considered for the outline of gene panels and the amount of pre-test genetic counselling. Mainstream genetic testing is mainly performed to stratify patients for targeted treatment. In addition, identification of germline pathogenic variants in cancer risk genes may have surgical implications, consequences for surveillance of other organs at risk of cancer, as well as family implications among relatives at risk. To ensure that patients are well informed, the introduction of mainstream genetic testing performed by non-genetic health care specialists requires an adapted pre-test counselling visit. Here, we review the literature and propose a web-based educational session and pocket guide to support implementation of mainstream testing in oncology practice.

Identifiers

PMID41634350
PMCPMC12867965

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.