Evidence map›Paper›PMID 41634280›Full record

ArticleJournal of natural medicines2026

New cerebrosides from the polar starfish Leptasterias polaris acervata and their cardioprotective and anti-inflammatory activity.

Viktor M Zakharenko, Timofey V Malyarenko, Alla A Kicha, Anatoly I Kalinovsky, Roman S Popov, Ekaterina A Chingizova, Ekaterina A Yurchenko, Natalia V Ivanchina

Abstract read
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Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Viktor M ZakharenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, Vladivostok, 690022, Russia. zakharenko.vm@yandex.ru.ORCID http://orcid.org/0000-0001-5809-6250
Timofey V MalyarenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, Vladivostok, 690022, Russia. malyarenko-tv@mail.ru.
Alla A KichaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, Vladivostok, 690022, Russia.
Anatoly I KalinovskyG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, Vladivostok, 690022, Russia.
Roman S PopovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, Vladivostok, 690022, Russia.
Ekaterina A ChingizovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, Vladivostok, 690022, Russia.
Ekaterina A YurchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, Vladivostok, 690022, Russia.
Natalia V IvanchinaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, Vladivostok, 690022, Russia.

Funding

Russian Science Foundation (RSF) No. 23-14-00040
6 · The paper itself

Abstract

Two new cerebrosides leptasteriacerebroside A (1) and B (2) were isolated from the starfish Leptasterias polaris acervata, together with two known ones (2S,3R,4E,9Z)-1-O-(β-D-glucopyranosyl)-2-[(2R)-2-hydroxyhexadecanoylamino]-4,9-docosadien-3-ol (3) and astrocerebroside B (4). The structures of the isolated compounds were characterized using spectroscopic techniques HRESIMS, ESIMS/MS, 1D and 2D NMR as well as by chemical modification and subsequent analysis of derivatives. The antimicrobial, urease inhibitory, cytotoxic, and cytoprotective activities of compounds 1–4 were investigated. Notably, compound 1 exhibited significant protection of H9c2 cardiomyocytes against CoCl2-induced toxicity, while compounds 2 and 4 demonstrated efficacy in mitigating TNF-α-mediated cytotoxicity, likely through inhibition of the NF-κB-dependent inflammatory pathway.

Indexed as

Anti-Inflammatory AgentsCardiotonic AgentsCerebrosidesStarfishAnimalsCell LineMolecular StructureMyocytes, CardiacNF-kappa BRatsTumor Necrosis Factor-alphaAnti-Inflammatory AgentsCardiotonic AgentsCerebrosidesNF-kappa BTumor Necrosis Factor-alphaCardioprotective activityCerebrosideLeptasterias polaris acervataSphingolipidStarfish

Identifiers

PMID41634280

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.