Evidence map›Paper›PMID 41634269›Full record

ArticleCardiovascular intervention and therapeutics2026

Left atrial appendage closure after a hospital admission for bleeding in atrial fibrillation patients: frequency, associated factors and prognosis.

Lucas Barreiro Mesa, Martín Ruiz Ortiz, Alejandro Recio Mayoral, Alejandro Reina Moreno, Jaime Nevado Portero, Carlos Del Toro Esperón, Javier Torres Llergo, Ana María Martínez Rodríguez, Laura Jordán Martínez, Ismael Arco Adamuz and 27 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Cardiovascular intervention and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Lucas Barreiro Mesa *Cardiology Department, University Hospital Reina Sofía, University of Córdoba, Córdoba, Spain.
Martín Ruiz Ortiz *Cardiology Department, University Hospital Reina Sofía, University of Córdoba, Córdoba, Spain. maruor@gmail.com.ORCID http://orcid.org/0000-0002-1479-7044
Alejandro Recio MayoralCardiology Department, University Hospital Virgen Macarena, Sevilla, Spain.
Alejandro Reina MorenoCardiology Department, University Hospital Virgen Macarena, Sevilla, Spain.
Jaime Nevado PorteroCardiology Department, University Hospital Virgen del Rocio, Sevilla, Spain.
Carlos Del Toro EsperónCardiology Department, University Hospital Virgen del Rocio, Sevilla, Spain.
Javier Torres LlergoCardiology Department, University Hospital of Jaén, Jaén, Spain.
Ana María Martínez RodríguezCardiology Department, University Hospital of Jaén, Jaén, Spain.
Laura Jordán MartínezCardiology Department, University Hospital Virgen de las Nieves, IBS.GRANADA, Granada, Spain.
Ismael Arco AdamuzCardiology Department, University Hospital Virgen de las Nieves, IBS.GRANADA, Granada, Spain.
Aurora María Martínez BallestaCardiology Department, University Hospital Virgen de las Nieves, IBS.GRANADA, Granada, Spain.
Víctor Manuel López EspinosaCardiology Department, University Hospital Virgen de las Nieves, IBS.GRANADA, Granada, Spain.
José Luis Delgado PrietoCardiology Department, University Hospital Regional de Málaga, Málaga, Spain.
Leopoldo Fernández RuzCardiology Department, University Hospital Regional de Málaga, Málaga, Spain.
Ana Delia Ruiz DuthilCardiology Department, University Hospital Clínico San Cecilio, Granada, Spain.
Cristina Cánovas GalindoCardiology Department, University Hospital Clínico San Cecilio, Granada, Spain.
Sara Corpas PérezCardiology Department, University Hospital Clínico San Cecilio, Granada, Spain.
Alejando Isidoro Pérez CabezaCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.
Alberto Contreras MuñozCardiology Department, University Hospital Virgen de la Victoria, Málaga, Spain.
Livia GheorgeCardiology Department, University Hospital Puerta del Mar, Cádiz, Spain.
Mauricio Urgiles OrtizCardiology Department, University Hospital Puerta del Mar, Cádiz, Spain.
Marina Teresa García GarcíaCardiology Department, University Hospital Puerta del Mar, Cádiz, Spain.
Jesús Aceituno CuberoCardiology Department, Hospital Torrecárdenas, Almería, Spain.
Gregorio Soto RojasCardiology Department, Hospital Torrecárdenas, Almería, Spain.
Beatriz Girela PérezCardiology Department, Hospital Torrecárdenas, Almería, Spain.
Sara Ballesteros PradasCardiology Department, University Hospital Virgen de Valme, Sevilla, Spain.
Virginia Pérez RamírezCardiology Department, University Hospital Virgen de Valme, Sevilla, Spain.
Almudena Valle AlbercaCardiology Department, Hospital Costa del Sol, Marbella, Málaga, Spain.
Susana Pérez CórdobaCardiology Department, Hospital Costa del Sol, Marbella, Málaga, Spain.
José Javier Sánchez FernándezCardiology Department, University Hospital de Puerto Real, Puerto Real, Cádiz, Spain.
Beatriz Calvo BernalCardiology Department, University Hospital de Puerto Real, Puerto Real, Cádiz, Spain.
Antonio Enrique Gómez MencheroCardiology Department, Hospital Juan Ramon Jiménez, Huelva, Spain.
Carmen Lluch RequereyCardiology Department, Hospital Juan Ramon Jiménez, Huelva, Spain.
Ana Del Río LechugaCardiology Department, Hospital de Jerez de la Frontera, Jerez de la Frontera, Cádiz, Spain.
Juan José Serrano SilvaCardiology Department, Hospital de Jerez de la Frontera, Jerez de la Frontera, Cádiz, Spain.
Rafael González González ManzanaresCardiology Department, University Hospital Reina Sofía, University of Córdoba, Córdoba, Spain.
Dolores Mesa RubioCardiology Department, University Hospital Reina Sofía, University of Córdoba, Córdoba, Spain.

Funding

Abbott Medical NAAndalusian Society of Cardiology NABoston Scientific International NA
6 · The paper itself

Abstract

There are no "real world" data on the actual impact of percutaneous left atrial appendage closure (LAAC) programs in the management of anticoagulated patients with atrial fibrillation (AF) after a hospital admission for bleeding. Our aim was to investigate the frequency, associated factors and prognostic impact of LAAC in the management of this population. All anticoagulated AF patients discharged alive from January 2021 to December 2022 after an intracranial or gastrointestinal haemorrhage, in the 15 public hospitals with LAAC program in Andalusia (South of Spain) were included in the study. Frequency, associated factors and prognostic impact of LAAC were investigated. Among a population of 7.119.044 inhabitants, 1403 patients were included (median age 81[p25-75, 76-87] years, 51.6% male). A LAAC procedure was performed in 114 patients (8.13%, 95%CI 6.70-9.56%) at 5 [2-10] months after discharge. LAAC was independently associated with tertiary referral centre, intracranial haemorrhage, previous bleeding, valvular heart disease, leukaemia and aspirin use while it was more infrequent in aged > 80 years, dementia, uncontrolled hypertension, vitamin K antagonist use and interventional treatment of the bleeding event (p < 0.05). After the procedure, the LAAC group had a better survival free from embolic/bleeding events and all-cause death (66% versus 49%) and overall survival (82% versus 64%) at 24 months (p < 0.05), consistent after multivariate adjustment: HR 0.65[0.46-0.92] and HR 0.52[0.32-0.86], respectively (p < 0.05). In our study, LAAC was infrequently performed after a severe bleeding in anticoagulated AF patients, although it was associated with better prognosis.

Indexed as

AnticoagulantsAtrial AppendageAtrial FibrillationLeft Atrial Appendage ClosureStrokeAgedAged, 80 and overFemaleHumansMalePrognosisRetrospective StudiesRisk FactorsSpainAnticoagulantsAnticoagulantsAtrial fibrillationBleedingLeft atrial appendage closurePrognosis.

Identifiers

PMID41634269

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.