Evidence map›Paper›PMID 41634132›Full record

ArticleScientific reports2026

Determination of hydrocortisone and cortisone in artificial saliva by spray assisted fine droplet formation liquid phase microextraction coupled to LC-MS/MS.

Selim Gürsoy, Süleyman Bodur, Arda Atakol, Sezgin Bakırdere

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Selim GürsoyDeparment of Analytical Chemistry School of Pharmacy, İstanbul Medipol University, 34810, Istanbul, Turkey.
Süleyman BodurFaculty of Art and Science Department of Chemistry, Yıldız Technical University, 34220, Istanbul, Turkey.
Arda AtakolFaculty of Pharmacy Department of Analytical Chemistry, Kent University, 34406, Istanbul, Turkey.
Sezgin BakırdereFaculty of Art and Science Department of Chemistry, Yıldız Technical University, 34220, Istanbul, Turkey. bsezgin23@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrocortisone and cortisone are clinically informative steroids whose joint measurement at low concentrations is essential for ratio-reliable interpretation. A spraying-assisted fine droplet formation liquid-phase microextraction (SA-FDF-LPME) was combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for simultaneous quantitation in saliva-type matrices as part of a method-development study. Method parameters were optimized to secure chromatographic resolution, stable ion ratios, and high sensitivity. Under direct injection, LOD/LOQ values were 1.05/3.50 µg kg

Indexed as

CortisoneHydrocortisoneLiquid Chromatography-Mass SpectrometryLiquid Phase MicroextractionSaliva, ArtificialTandem Mass SpectrometryChromatography, LiquidHumansLimit of DetectionSalivaCortisoneHydrocortisoneSaliva, ArtificialArtificial salivaCortisoneHydrocortisoneSpraying assisted fine droplet formation liquid phase microextractionTandem mass spectrometry

Identifiers

PMID41634132
PMCPMC12921225

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.