ArticleCommunications medicine2026
Nutrition in early life interacts with genetic risk to influence preadult behaviour in the Raine Study.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundEarly life nutrition is associated with child behaviour; however, the interplay with genetic vulnerability is understudied. We hypothesised that psychiatric genetic risk interacted with early nutrition to predict behavioural problems in childhood and adolescence.
methodsThe Raine Study participants with genetic information aged 2-17 were repeatedly evaluated with the child behaviour checklist total problems score (CBCL
resultsIn 1393 participants, a borderline signal suggests that 1 month longer breastfeeding reduces CBCL
conclusionsNutrition in early life and psychiatric genetic risk may interact to determine lasting child behaviour. Contrary to our hypothesis, we find dietary benefits in individuals with lower ADHD PGS, necessitating replication. We also highlight the possibility of including genetics in early nutrition intervention trials for causal inference.
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