Evidence map›Paper›PMID 41634068›Full record

ArticleScientific reports2026

Development and validation of a green analytical method to determine bromhexine hydrochloride in pharmaceuticals.

Salwa Kh Mohamed, Deena A Nour-Eldeen, Mahmoud A Omar

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Salwa Kh MohamedAnalytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, 61511, Egypt.
Deena A Nour-EldeenAnalytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, 61511, Egypt.
Mahmoud A OmarAnalytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, 61511, Egypt. momar71g@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erythrosine B (EB) is a food colorant and antiviral xanthene dye that is widely used as a color additive in pharmaceutical and cosmetic industries. Its application as a sensor for spectrophotometric measurement of amine-based pharmaceuticals offers several benefits due to its availability, low cost, quick labeling, and high sensitivity. In the present study, a quick, sensitive and simple green spectrophotometric method has been developed to assay Bromhexine Hydrochloride (BMH) in pure form and its pharmaceutical formulation. The spectrophotometric methodology reveals complex development between the drug and erythrosine B at 556 nm at pH 3.6. The spectrophotometric absorbance-concentration curve is linear over the ranges (1.0-9.0 μg mL

Indexed as

BromhexineGreen Chemistry TechnologyErythrosineLimit of DetectionPharmaceutical PreparationsReproducibility of ResultsSpectrophotometryBromhexineErythrosinePharmaceutical PreparationsBlue and green profile evaluationBromhexine hydrochlorideErythrosine BSpectrophotometric determinationWhite

Identifiers

PMID41634068
PMCPMC12877044

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.