ArticleNature communications2026
A multi-ancestry genetic reference for the Quebec population.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- A transparent and generalizable deep-learning framework for genomic ancestry prediction.American journal of human genetics · 2026Article
- Optimal Reference Panel Design in Ancient DNA Imputation from Coalescent Theory, Simulation, and Real Data Application with an Ancient Reference Panel.bioRxiv : the preprint server for biology · 2026Article
- Fine-scale structure of a whole regional population through genetics and genealogies.Nature communications · 2026Article
- Topological stratification of continuous genetic variation in large biobanks.PLoS genetics · 2026Article
- A multi-ancestry genetic reference for the Quebec population.Nature communications · 2026Article
- Using the ancestral recombination graph to study the history of rare variants in founder populations.American journal of human genetics · 2025Article
- ODAD4-Related Primary Ciliary Dyskinesia: Report of Five Cases and a Founder Variant in Quebec.Cells · 2025Article
- Rare variants and founder effect in the Beauce region of Quebec.Communications biology · 2025Article
Corrections and comments
- Update of
Authors and funding
34 authors.
Funding
Abstract
While international efforts have characterized genetic variation in millions of individuals, the interplay of environmental, social, cultural and genetic factors is poorly understood for most worldwide populations. The province of Quebec in Canada has been the site of numerous genetic studies, often focusing on Mendelian diseases in founder sub-populations. Here, we analyze genome-wide genotyped variation in 29,337 Quebec residents from the multi-ancestry population-based cohort CARTaGENE (CaG) who provided DNA samples. We also sequence the whole-genome of 2,173 CaG participants with four grandparents born in Canada (n = 1879), Haiti (n = 163) and Morocco (n = 131). We use this genetic information to gain insight into Quebec's demography and to help interpret the potential significance of variants identified in clinically important genes (e.g., SPG7 implicated in hereditary spastic paraplegia). We validate an imputation panel constructed by phasing the CaG whole-genome sequence data and find, using genome-wide association studies (GWAS) of 42 clinically relevant traits, that it increases the number of associated loci by ~7% when compared to results obtained after imputation with the larger TOPMed imputation panel. We provide allele frequency information and GWAS results through dedicated and publicly available websites. The genetic data, paired with phenotypic and environmental information, is available for global research use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.