Evidence map›Paper›PMID 41633983›Full record

Trial reportTranslational psychiatry2026

Minocycline attenuates panicogenic responses in a CO

Beatriz F G de Oliveira, Laiana A Quagliato, Alana T Frias, Luis Gustavo A Patrone, Elisa M Fonseca, Maria Emanuelle Reis, Breno Vilas Boas Raimundo, Karen Cristina Oliveira, Mariana Marchi Santoni Biasioli, Caroline Maria Marcos and 8 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Beatriz F G de Oliveira *Dept of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, SP, Brazil.
Laiana A Quagliato *Laboratory of Panic and Respiration (LABPR); Institute of Psychiatry of Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0002-6928-5847
Alana T FriasDept of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, SP, Brazil.ORCID http://orcid.org/0000-0002-0571-2539
Luis Gustavo A PatroneDept of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, SP, Brazil.ORCID http://orcid.org/0000-0002-8270-1892
Elisa M FonsecaDept of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, SP, Brazil.
Maria Emanuelle ReisDept of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, SP, Brazil.
Breno Vilas Boas RaimundoDepartment of Biological Sciences. School of Pharmaceutical Sciences. São Paulo State University (UNESP), Araraquara, SP, Brazil.
Karen Cristina OliveiraDepartment of Biological Sciences. School of Pharmaceutical Sciences. São Paulo State University (UNESP), Araraquara, SP, Brazil.
Mariana Marchi Santoni BiasioliDepartment of Biological Sciences. School of Pharmaceutical Sciences. São Paulo State University (UNESP), Araraquara, SP, Brazil.
Caroline Maria MarcosLaboratory of Biology, Control and Surveillance of Insect Vectors, Oswaldo Cruz Institute, FIOCRUZ/RJ, Rio de Janeiro, Brazil.
Tatiana Maria de Souza-MoreiraDepartment of Biological Sciences. School of Pharmaceutical Sciences. São Paulo State University (UNESP), Araraquara, SP, Brazil.
Felipe Dalvi-GarciaLaboratory of Panic and Respiration (LABPR); Institute of Psychiatry of Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0003-0544-8034
Natia HoratoLaboratory of Panic and Respiration (LABPR); Institute of Psychiatry of Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0003-0883-2015
Kênia C BícegoDept of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, SP, Brazil.
Hélio ZangrossiDepartment of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Alexandra Ivo de MedeirosDepartment of Biological Sciences. School of Pharmaceutical Sciences. São Paulo State University (UNESP), Araraquara, SP, Brazil.
Antonio E NardiLaboratory of Panic and Respiration (LABPR); Institute of Psychiatry of Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0002-2152-4669
Luciane H GargaglioniDept of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, SP, Brazil. luciane.gargaglioni@unesp.br.ORCID http://orcid.org/0000-0003-4097-5286

Funding

Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) 302991/2022-0
6 · The paper itself

Abstract

There is a connection between neuroinflammation and panic attacks (PA), as microglia-driven pro-inflammatory responses help detect homeostatic disturbances like CO₂ inhalation. This model has become widely used in research since CO₂ exposure can trigger PA in humans and panic-related behavior in mice. Minocycline inhibits microglia activation, serving as a promising tool to attenuate CO

Indexed as

Anti-Bacterial AgentsLocus CoeruleusMicrogliaMinocyclineNeuroinflammatory DiseasesPanic DisorderAdolescentAdultAgedAnimalsCarbon DioxideClonazepamFemaleHumansHypercapniaMaleAnti-Bacterial AgentsCarbon DioxideClonazepamMinocycline

Identifiers

PMID41633983
PMCPMC12923763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.