Evidence map›Paper›PMID 41633982›Full record

ArticleTranslational psychiatry2026

Echoes of childhood trauma: the relationship between adverse childhood experiences, brain structure, and mental health in aging adults.

Anne Klimesch, Leonie Ascone, Götz Thomalla, Bastian Cheng, Marvin Petersen, Ingo Schäfer, Jürgen Gallinat, Simone Kühn

Abstract read
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anne KlimeschDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20251, Hamburg, Germany. a.klimesch@uke.de.ORCID http://orcid.org/0000-0003-3345-372X
Leonie AsconeDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20251, Hamburg, Germany.
Götz ThomallaDepartment of Neurology, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20251, Hamburg, Germany.
Bastian ChengDepartment of Neurology, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20251, Hamburg, Germany.ORCID http://orcid.org/0000-0003-2434-1822
Marvin PetersenDepartment of Neurology, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20251, Hamburg, Germany.ORCID http://orcid.org/0000-0001-6426-7167
Ingo SchäferDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20251, Hamburg, Germany.
Jürgen GallinatDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20251, Hamburg, Germany.
Simone KühnDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20251, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adverse childhood experiences (ACEs) are associated with persistent mental health risks and brain structural differences across adulthood, yet their long-term neurobiological relevance in aging populations remains unclear. Given that ACEs are common and societies are aging, understanding how early adversity relates to mental and brain health across the lifespan is an important goal. This preregistered study examined whether ACEs are associated with mental health symptoms in mid- to late adulthood, and whether regional brain structure may account for part of this relationship. Cross-sectional data of the Hamburg City Health Study were used, involving participants aged 46-78 years with available magnetic resonance imaging data (N

Indexed as

Adult Survivors of Child Adverse EventsAdverse Childhood ExperiencesAgingBrainMental HealthAgedAmygdalaCross-Sectional StudiesFemaleGray MatterHippocampusHumansMagnetic Resonance ImagingMaleMiddle Aged

Identifiers

PMID41633982
PMCPMC12873319

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.