Evidence map›Paper›PMID 41633823›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2026

Multicentre validation of a patient-reported outcome measure for functional movement disorders.

Rosa Michaelis, Leonie Hagedorn, Anne Weissbach, Christoph van Riesen, Kirsten E Zeuner, Tamara Schmidt, Christina Bolte, Felix Bernsdorff, Maximilian J Löw, Carl A Gless and 7 more

Abstract readMulticenter StudyValidation Study
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rosa MichaelisDepartment of Neurology, Knappschaft Kliniken University Hospital Bochum, Ruhr University Bochum, Bochum, Germany rosa.michaelis@knappschaft-kliniken.de.ORCID http://orcid.org/0000-0002-2577-0824
Leonie HagedornDepartment of Neurology, Knappschaft Kliniken University Hospital Bochum, Ruhr University Bochum, Bochum, Germany.
Anne WeissbachInstitute of Systems Motor Science, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0002-3569-6242
Christoph van RiesenDepartment of Neurology, University Medical Centre Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0003-1734-2421
Kirsten E ZeunerDepartment of Neurology, Christian Albrecht University of Kiel, Kiel, Germany.
Tamara SchmidtMovement Disorders Hospital Beelitz-Heilstätten, Kliniken Beelitz GmbH, Beelitz, Germany.
Christina BolteInstitute of Systems Motor Science, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0009-0006-2229-104X
Felix BernsdorffDepartment of Neurology, University Medical Centre Göttingen, Göttingen, Germany.
Maximilian J LöwDepartment of Neurology, University Medical Centre Göttingen, Göttingen, Germany.
Carl A GlessDepartment of Radiology and Neuroradioloy, Christian Albrecht University of Kiel, Kiel, Germany.ORCID http://orcid.org/0009-0000-8579-4089
Annemarie ReinckeDepartment of Neurology, Christian Albrecht University of Kiel, Kiel, Germany.
Desiree SykoraMovement Disorders Hospital Beelitz-Heilstätten, Kliniken Beelitz GmbH, Beelitz, Germany.
Kathrin LaFaverDivision of Neurology, Saratoga Hospital, Saratoga Springs, New York, USA.
Alexander C LehnDepartment of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-3551-7010
Christoph KleinschnitzDepartment of Neurology and Centre for Translational and Bahavioral Neurosciences (C-TNBS), University Medicine Essen, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-1650-8875
Corinna SeligerDepartment of Neurology, Knappschaft Kliniken University Hospital Bochum, Ruhr University Bochum, Bochum, Germany.ORCID http://orcid.org/0000-0002-4923-4495
Stoyan PopkirovDepartment of Neurology and Centre for Translational and Bahavioral Neurosciences (C-TNBS), University Medicine Essen, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0001-6168-0036

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNo disorder-specific patient-reported outcome measure (PROM) has yet been validated for functional movement disorders (FMDs), leaving a critical gap in clinical care and research.

objectiveTo validate the FMD questionnaire (FMDQ) in a prospectively recruited sample through a multicentre study.

methodsConfirmatory factorial analysis (CFA) tested the assumed structure of the questionnaire with factors reflecting severity of motor symptoms, impairment of everyday activities, impact of non-motor symptoms and impairment of social functioning. Internal consistency and floor/ceiling effects were examined. The 36-item short form health survey (SF-36), patient health questionnaire-15 (PHQ-15), the fatigue assessment scale (FAS) and a clinician-rated scale corresponding to motor symptom items of the FMDQ (FMDQ-CR) were used to test criterion and construct validity. The minimally clinically important difference (MCID) was assessed through distribution-based and anchor-based methods in a convenience sample of patients with follow-up assessments.

resultsComplete datasets from 157 patients were analysed; follow-up assessments were available from 30 patients. CFA confirmed that a four-factor model provides a better fit to the data compared with a more restrictive one-factor model. Internal consistency was appropriate for all factors/subscales. No floor or ceiling effects were detected. Criterion and content validity were supported by significant correlations with respective SF-36 subscores, PHQ-15, FAS and FMDQ-CR. Anchor-based MCID was estimated at 8 to 20 points, with the central value aligning with the distribution-based MCID of 12 points (8% of the total score range).

conclusionsThe FMDQ is a psychometrically robust PROM, making it a useful tool for clinical practice and treatment trials.

Indexed as

Movement DisordersPatient Reported Outcome MeasuresAdultAgedFemaleHumansMaleMiddle AgedMinimal Clinically Important DifferenceProspective StudiesPsychometricsReproducibility of ResultsSurveys and QuestionnairesFUNCTIONAL NEUROLOGICAL DISORDERPatient Outcome AssessmentQUALITY OF LIFE

Identifiers

PMID41633823
PMCPMC13151429

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.