Evidence map›Paper›PMID 41633761›Full record

ArticleBMJ paediatrics open2026

Impact of the COVID-19 pandemic on infant neurodevelopmental outcomes.

Yuki Kyono, Masahiro Nishiyama, Hiroshi Yamaguchi, Aoi Kawamura, Shizuka Oikawa, Shoichi Tokumoto, Takumi Imai, Sae Murakami, Kandai Nozu, Hiroki Mishina and 1 more

Abstract read
In one paragraph

Article in BMJ paediatrics open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuki KyonoDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Masahiro NishiyamaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan nishiya@med.kobe-u.ac.jp.ORCID http://orcid.org/0000-0002-5437-314X
Hiroshi YamaguchiDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Aoi KawamuraDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Shizuka OikawaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Shoichi TokumotoDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Takumi ImaiClinical and Translational Research Center, Kobe University Hospital, Kobe, Japan.
Sae MurakamiClinical and Translational Research Center, Kobe University Hospital, Kobe, Japan.
Kandai NozuDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Hiroki MishinaKobe City Child and Family Bureau, Kobe, Japan.
Hiroaki NagaseDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis population-based cohort study in Kobe, Japan, investigated the impact of the COVID-19 pandemic on infant neurodevelopment by comparing children born before and during the pandemic.

designRetrospective population-based cohort study of 63 703 children born between 1 April 2014 and 31 October 2020, who underwent an 18-month health check-up.

settingKobe, Japan. PATIENT: Children born between April 2014 and March 2018 (pre-COVID-19 group) or April-October 2020 (during-COVID-19 group).

interventionNone

main outcome measuresNeurodevelopmental outcomes assessed by trained paediatricians, including language, social and behavioural indicators.

resultsThe abnormal neurodevelopment prevalence was higher in the during-COVID-19 group (12.8%) than in the pre-COVID-19 group (10.2%) (OR, 1.30; 99% CI 1.16 to 1.46). Similarly, the rate of children without meaningful words was higher during the pandemic (7.1% vs 4.8%; OR, 1.52; 99% CI 1.31 to 1.78), indicating delayed language development. Intergroup differences in other outcomes were minimal.

conclusionsThe COVID-19 pandemic may have negatively influenced early neurodevelopment, particularly language acquisition. These findings suggest that infant language development is affected by social changes, such as pandemics. Further research is required to explore the underlying causes and the long-term effects.

Indexed as

Child DevelopmentCOVID-19Neurodevelopmental DisordersFemaleHumansInfantJapanMaleNeurodevelopmentPandemicsRetrospective StudiesSARS-CoV-2Child HealthCOVID-19

Identifiers

PMID41633761
PMCPMC12878251

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.