Evidence map›Paper›PMID 41633701›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[Optimized extraction of active components of

Qiao Xu, Wenjie Li, Xinyue Zhang, Yue Chen, Zitong Jiang, Guangzhe Li, Mingming Yan

Abstract readEnglish Abstract
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiao XuChangchun University of Traditional Chinese Medicine College of Pharmacy, Changchun 130117, China.
Wenjie LiChangchun University of Traditional Chinese Medicine College of Pharmacy, Changchun 130117, China.
Xinyue ZhangChangchun University of Traditional Chinese Medicine College of Pharmacy, Changchun 130117, China.
Yue ChenChangchun University of Traditional Chinese Medicine College of Pharmacy, Changchun 130117, China.
Zitong JiangChangchun University of Traditional Chinese Medicine College of Pharmacy, Changchun 130117, China.
Guangzhe LiChangchun University of Traditional Chinese Medicine College of Pharmacy, Changchun 130117, China.
Mingming YanChangchun University of Traditional Chinese Medicine College of Pharmacy, Changchun 130117, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo optimize the extraction process of the active components of Radix

resultsThe optimized parameters for BST extraction included 50% ethanol, liquid-to-solid ratio of 15:1, extraction time of 1 h, and 20-mesh particle size. BST exhibited strong free radical-scavenging activity and significantly reduced melanogenesis and increased tyrosinase protein in B16 cells, and lowered ROS production in HaCaT cells. In the mouse models of melanogenesis, BST significantly suppressed the melanogenic enzymes and inflammatory responses by reducing the levels of tyrosinase and TNF-α, thereby effectively reversed UVB-induced photoaging and hyperpigmentation.

conclusionsThe optimized BST extraction process is stable and predictable. BST shows good skin-whitening effect, which is mediated possibly by inhibiting tyrosinase activity and modulating oxidative stress and inflammatory pathways.

Indexed as

Anti-Inflammatory AgentsAntioxidantsPaeoniaSkin Lightening PreparationsSkin PigmentationAnimalsHumansMelaninsMelanogenesisMiceMonophenol MonooxygenasePlant ExtractsAnti-Inflammatory AgentsAntioxidantsMelaninsMonophenol MonooxygenasePlant ExtractsSkin Lightening Preparationsantioxidant effectB16 cellsHacat cellsskin whiteningunivariate-response surface methodwhite peony extract

Identifiers

PMID41633701
PMCPMC12867650

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.